白细胞介素8、白细胞介素10与肠道炎症关系研究进展

The Progress of the Relationship between IL-8、IL-10 and the Inflammation of Intestinal Tract

细胞因子白细胞介素8(IL-8)和IL-10各有其显著的特点,在肠道炎症性的免疫反应中有十分重要的作用。IL-8是一种致炎因子,同时也是一种趋化因子,在致炎过程中,它与其他的炎性因子有相互促进的作用;IL-10是一种抑炎因子,在炎性反应中它可以抑制炎性免疫反应,使机体或细胞免受进一步的损害。深入研究这两种细胞因子对于溃疡性结肠炎、克罗恩病及慢性末端回肠炎的治疗、预防有重要意义。

Cytokines IL-8 and IL-10 have their own conspicuous characteristics, they play important roles in the inflammatory immune reaction of intestinal tract. IL-8 is an inflammatory factor,and it is a chemotatie factor simultaneously. During the inflammatory process, IL-8 and other inflammatory factors could facilitate each other; IL-10 is an inhibitory inflammationary factor which could inhibit inflammatory immunereaetions and prevent the organism and cells from being injured. To make a further study of this two kinds of eytokines has a great significance on the therapy and prophylaxis of the ulcerative eolilis,Crohn disease and the chronic terminal ileitis.