大动脉僵硬及一氧化氮的调节作用

The Regulation of Nitric Oxide in Large Artery Stiffness

高血压、糖尿病、吸烟等心血管病危险因素均可导致动脉僵硬,其主要的临床表现是单纯的收缩期高血压和脉压差增大。大动脉僵硬与动脉粥样斑块的发展密切相关。目前评估大动脉僵硬的方法主要有脉压差和主动脉脉搏速度等。肾上腺素、去甲肾上腺素和血管内皮细胞释放的一氧化氮(NO)和内皮素1对大动脉僵硬具有调节作用。本文对大动脉僵硬及NO的调节作用进行综述。

Hypertension, diabetes and cigarette smoking, which are called as cardiovascular risk, cause arterial stiffness With systolic hypertension and wide pulse pressure as major clinical manifestations. Stiffness may also associate with the development of atherosclerotic plaques. The aortic pulse wave velocity and pulse pressure are used in evaluation of arterial stiffness. Adnephrin, noradrenaline, nitric oxide （NO） and endothelin-1, which released by the endothelial cells, can regulate large artery stiffness. This article reviewed the recent researches in large artery stiffness and its regulation by NO.