摘要
内皮祖细胞是血管内皮细胞的前体细胞,目前较多研究提示其在冠心病中的治疗作用。雌激素可能影响冠心病的病理生理过程和预后,但其益处仍未得到肯定。已经有较多证据显示雌激素可通过促进内皮祖细胞的动员、增殖、归巢、分化并减少其凋亡,从而增加内皮修复和血管新生,最终达到减轻心脏缺血性损伤,改善心脏功能的作用。由于内皮祖细胞的长期作用仍缺乏研究,而通过内皮祖细胞对冠心病发挥影响也很可能仅是雌激素的部分作用,雌激素在冠心病的预防和治疗方面的益处依然需要更多的研究以证实。
It has been found that estrogen may influence the pathophysiologic process and prognosis of coronary heart diseases. The endothelial progenitor cell is the precursor of the vascular endothelial cell. Current research indicates the endothelial progenitor cell （ EPC ） has a therapeutic application in coronary arteriosclerosis. Research has proven that estrogen can promote EPC mobilization, proliferation, homing, differentiation and inhibit apoptosis in EPC, which promotes endothelial recovery and neovascularization. This results in protection from ischemic injury and preservation of heart function. However, for lacking long-teim researches and just partial effection of estrogen via EPC, the beneficial effect of estrogen for coronary heart disease still needs more researches.
出处
《心血管病学进展》
CAS
2008年第6期858-862,共5页
Advances in Cardiovascular Diseases
关键词
冠心病
雌激素
内皮祖细胞
coronary heart disease
estrogen
endothelial progenitor cell
