非ST段抬高急性冠脉综合征患者药物洗脱支架置入术后强化抗血小板治疗研究进展

Advances in Research in Extensive Antiplatelet Therapy after DES Implantation for Patients with NSTE-ACS

药物洗脱支架可显著改善非ST段抬高急性冠脉综合征患者的心血管终点。一方面,药物支架通过抑制平滑肌细胞的增生使再狭窄率大大降低;另一方面,它又可抑制内皮细胞的增殖而导致内皮化延迟,从而有可能增加支架内血栓,尤其是晚期支架内血栓的发生风险。冠状动脉介入术后强化抗血小板策略作为预防这一危及生命的临床事件的重要手段之一,在药物洗脱支架时代已受到广泛的关注。

The use of drug-eluting stent （ DES） demonstrates a significant improvement in cardiovascular end points in patients with non-ST-segment-elevation acute coronary syndrome （ NSTE-ACS）. On the one hand, DES inhibits the proliferation of smooth muscle cells and dramatically reduces the rate of restenosis. On the other hand, it also suppresses the proliferation of endothelial cells and results in delayed endothelialization, which may increase the risk of stent thrombosis , especially late stent thrombosis. Extensive antiplatelet strategy after percutaneous coronary intervention, is ＇one of most important methods in preventing the life-threatening clinical event and DES era has been a focus of public attention.