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非酒精性脂肪性肝病动物模型的评价 被引量：2

Evaluation of animal models of nonalcoholic fatty liver disease
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摘要 非酒精性脂肪性肝病（NAFLD）发病机制至今尚未完全阐明，治疗上亦缺乏有效措施。为此，亟待加强NAFLD发病机制及防治的研究，动物模型有望在此方面弥补临床研究的不足。理想的NAFLD模型应与人类疾病谱相似并且病变分期明显，从单纯性脂肪肝经非酒精性脂肪性肝炎（NASH）最终发生肝硬化和肝细胞癌（HCC）；模型形成率高，病死率低；
作者 乔梁 范建高
机构地区 香港大学玛丽医院消化内科 上海交通大学医学院附属新华医院消化内科
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2008年第11期806-808,共3页 Chinese Journal of Hepatology
关键词 脂肪肝 模型 动物 非酒精性脂肪性肝炎 Fatty liver Models, animal Nonalcoholic steatohepatitis
分类号 R575 [医药卫生—消化系统] R-332 [医药卫生]
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参考文献15

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  • 3Larter CZ. Not all models of fatty liver are created equal: under-standing mechanisms of steatosis development is important. J Gastroenterol Hepatol, 2007, 22: 1353-1354.
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  • 6Lu SC, Alvarez L, Huang ZZ, et al. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Nail Acad Sci U S A, 2001, 98: 5560-5565.
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共引文献5

同被引文献16

  • 1范建高.脂肪性肝病的流行现状及其自然史[J].现代实用医学,2006,18(7):445-447. 被引量：32
  • 2Shapiro H, Bruck R. Therapeutic potential of curcumin in non-al- coholic steatohepatitis. Nutr Res Rev, 2005, 18: 212-221.
  • 3Tang H, Murphy CJ, Zhang 13, et al. Amphiphilic curcumin conju- gate-forming nanoparticles as anticancer prodrug and drug carriers: in vitro and in vivo effects. Nanomedicine (Lond), 2010, 5: 855- 865.
  • 4Brunt EM, Janney CG, Di Bisceglie AM, et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Arn J Gastroenterol, 1999, 94: 2467-2474.
  • 5Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 2001, 25: 402-408.
  • 6Asai A, Miyazawa T. Dietary curcuminoids prevent high-fat diet- induced lipid accumulation in rat liver and epididymal adipose tissue. J Nutr, 2001, 131: 2932-2935.
  • 7Ramirez-Tortosa MC, Ramirez-Tortosa CL, Mesa MD, et al. Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Free Radic Biol Med, 2009, 47: 924-931.
  • 8Shishodia S, Singh T, Chaturvedi MM. Modulation of transcription factors by curcumin. Adv Exp Med Biol, 2007, 595: 127-148.
  • 9Babu PS, Srinivasan K. Hypolipidemic action of curcumin, the ac- tive principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Mol Cell Biochem, 1997, 166: 169-175.
  • 10Angulo P. GI epidemiology:nonalcoholic fatty liver disease[J].Alimentary Pharmacology and Therapeutics,2007.883-889.

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中华肝脏病杂志
2008年 第11期

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