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酒精性肝病大鼠肝组织解偶联蛋白2的表达 被引量：4

The expression of uncoupling protein 2 in the hepatic tissue of rats induced by ethanol
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摘要 解偶联蛋白（UCP）是线粒体内膜上可以调节质子跨膜转运的载体蛋白，具有解偶联活性，目前共发现5个亚型^[1-2]。其中UCP2通过调节质子跨膜转运参与能量消耗和脂质代谢，可能参与酒精性肝病（ALD）发病过程中的氧化应激与脂质过氧化。本研究旨在应用酒精灌胃建立大鼠ALD模型，动态观察UCP2蛋白及mRNA的表达情况，以探讨UCP2在ALD发病过程中的作用及其机制，为有效防治ALD提供新的理论依据。
作者 周俊英 王玮 赵彩彦 甄真
机构地区 河北医科大学第三医院感染科
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2008年第11期865-866,共2页 Chinese Journal of Hepatology
基金 基金项目：河北省科技厅计划项目（062761344）
关键词 肝疾病 酒精性 解偶联蛋白2 氧化应激 Liver diseases, alcoholic Uncoupling protein2 Oxidative stress
分类号 R575 [医药卫生—消化系统]
  • 相关文献

参考文献5

  • 1Ishizawa M, Mizushige K, Noma T, et al. An antioxidant treatment potentially protects myocardial energy metabolism by regulating uncoupling protein 2 expression in a chronic beta-adrenergic stimulation rat model. Life Sci, 2006, 78: 2974-2782.
  • 2Bragoszewski P, Habior A, Walewska-Zielecka B, et al. Expression of genes encoding mitochondrial proteins can distinguish nonalco- holic steatosis from steatohepatitis. Acta Biochim Pol, 2007, 54: 341-348.
  • 3Fulop P, Derdak Z, Sheets A, et al. Lack of UCP2 reduces Fasmediated liver injury in ob/ob mice and reveals importance of cell- specific UCP2 expression. Hepatology, 2006, 44: 592-601.
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  • 5范建高,丁晓东,王国良,徐正婕,田丽艳,郑晓英.非酒精性脂肪性肝病大鼠肝脏解偶联蛋白2表达及其与能量贮备的关系[J].中华肝脏病杂志,2005,13(5):374-377. 被引量：21

二级参考文献9

  • 1范建高,郑晓英,张梅,曹中伟,丁晓东.非酒精性脂肪性肝病大鼠肝脏纤溶酶原激活物及其抑制物mRNA表达[J].肝脏,2004,9(2):103-105. 被引量：6
  • 2Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis:summary of an AASLD Single Topic Conference. Hepatology, 2003,37: 1202-1219.
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  • 8Hourton-Cabassa C, Mesneau A, Miroux B, et al. Alteration of plant mitochondrial proton conductance by free fatty acids. Uncoupling protein involvement. J Biol Chem, 2002, 277: 41533-41538.
  • 9范建高.肥胖相关肝病的防治策略[J].中华肝脏病杂志,2004,12(4):255-256. 被引量：10

共引文献20

同被引文献31

  • 1Tipoe GL,Liong EC,Casey,CA,et al.A voluntary oral ethanolfeeding rat model associated with neeroinflammatory liver injury.Alcohol Clin Exp Res,2008,32:669-682.
  • 2Sampey BP,Korourian S,Ronis M J,et al.Immunohistoehemieal characterization of hepatic malondialdehyde and 4-hydroxynonanal modified proteins during early stages of ethanol-induced fiver injury.Alcohol Clin Exp Res,2003,27:1015-1022.
  • 3Basu S.Carbon tetrachloride-induced lipid peroxidation:eicosanoid formation and their regulation by antioxidant nutrients.Toxicology,2003,189:113-127.
  • 4Yu J,Ip E,Dela Pefia A,et al.COX-2 induction in mice with experimental nutritional steatohepatitis:Role as pro-inflammatory mediator.Hepatology,2006,43:826-836.
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  • 6Bjursell M, Ahnmark A, Bohlooly YM, et al. Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism [J]. Diabetes, 2007, 56(3) : 583 -593.
  • 7Yamauchi T, Nio Y, Maki T, et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions [ J ]. Nature Medicine, 2007, 13(3): 332-339.
  • 8Pontikides N, Krassas GE. Basic endocrine products of adipose tissue in states of thyroid dysfunction [ J ]. Thyroid, 2007, 17(5) : 421 -431.
  • 9Lim Paik-Seong, .Chen Shunliang, Wu Mingying,et al. Association of plasma adiponectin levels with oxidative stress in hemodialysis patients [ J ]. Blood Purif, 2007, 25 (4) : 362 - 369.
  • 10Kadowaki T, Yamauchi T, Kubato N, et al. Adiponectin and adiponectin receptors in obesity-linked insulin resistance [J]. Novartis Found Symp, 2007, 286(1):164 - 176.

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中华肝脏病杂志
2008年 第11期

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