摘要
目的研究三甲益肝冲剂对大鼠功能性消化不良的治疗作用及其可能机制。方法健康成年SD大鼠40只,随机分为空白对照组、模型组、莫沙必利组和三甲益肝冲剂组。测定各组大鼠胃排空,并测定大鼠血浆胃动素的含量。结果模型组大鼠胃排空和血浆胃动素的含量明显低于空白对照组(P<0.05)。经治疗后,莫沙必利和三甲益肝冲剂组明显升高,与模型组比较差异有统计学意义(P<0.05),而莫沙必利组和三甲益肝冲剂组之间差异无统计学意义。结论三甲益肝冲剂能通过升高血浆中胃动素的含量而促进胃排空,这可能是该方治疗功能性消化不良作用机制之一。
Objective To study the effect of sanjia-yigan granule on functional dyspepsia in rats. Methods All SD rats were randomly divided into control group, model group, mosapride group and sanjia-yigan granule group. Gastric emptying was observed with phenolsulfonphthalein ; and contents of motilin（MTL） in plasma were detected with radioimmunoassay. Results Compared to the control group,the contents of MTL and gastric emptying in model group were obviously decreased（ P 〈0. 05）. Sanjia-yigan granule increased the contents of MTL and accelerated gastric emptying significantly, and there was no significant difference between sanjia-yigan granule group and mosapride group. Conclusion Sanjia-yigan granule could conerease the contents of MTL in plasma and promote gastric emptying, which may be one of its therapeutic mechanism in treating functional dyspepsia.
出处
《临床消化病杂志》
2008年第5期285-287,共3页
Chinese Journal of Clinical Gastroenterology
