阿托伐他汀对不稳定型心绞痛患者PCI术后心肌损伤及炎症反应的影响

Effect of atorvastatin on myocardial injure and inflammatory reaction from PCI in patients with unstable angina pectoris

目的探讨阿托伐他汀常规剂量治疗对不稳定型心绞痛(UAP)患者经皮冠状动脉介入术(PCI)后,心肌损伤的标记物血清肌酸磷酸激酶同功酶(CK-MB)、血浆肌钙蛋白Ⅰ(cTnI)及炎症反应标志物超敏C反应蛋白(hs-CRP)的变化。方法根据UAP患者PCI术前4周是否持续服用阿托伐他汀20mg/d分为试药组和对照组,于术前和术后8h、24h抽取肘静脉血检测血浆CK-MB、cTnI和hs-CRP。结果PCI术后两组心肌损伤及炎症反应的标记物均有不同程度升高,但试药组CK-MB、cTnI、hs-CRP水平显著低于对照组(均P<0.01)。结论UAP患者在PCI术前4周持续口服阿托伐他汀20mg/d能明显减少PCI术对UAP患者造成的心肌损伤及炎症反应。

AIM To study the effect of atorvastatin on percutaneous coronary intervention （ PCI ） in patients myocardial injure and with unstable angina inflammatory reaction from pectoris. The markers of myocardial injure are CK-MB and cardiac troponin （cTnI）. The marker of inflammatory reaction is high-sensitivity C-reactive protein （hs-CRP）. METHODS The two treatment groups received atorvastatin 20 mg daily or non-atorvastatin 4 successive weeks before PCI, CK-MB, cTnI and hs-CRP of the blood from elbow vein were monitored before and 8 and 24 hours after the procedure of PCI. RESULTS The markers of two groups were elevated after PCI, however, the ascended values of CK- MB, cTnI and hs-CRP in the atrovastatin treatment group were significantly lower than those of the compared group （ P 〈 0. 01 ）. CONCLUSION Administering 20 mg atorvastatin daily in 4 successive weeks before PCI can significantly reduce the myocardial injury and inflammatory reaction.