摘要
ATP结合盒转运体A1（ABCA1）是一种整合膜蛋白，它以ATP为能源，转运细胞内的游离胆固醇、磷脂至细胞外并与载脂蛋白A1结合，形成高密度脂蛋白。ABCA1基因是胆固醇逆转运和高密度脂蛋白（HDL）生成起始步骤的关键基因。ABCA1的表达在转录和转录后水平受肝X受体／视黄醇X受体（LXR／RXR）等多种因子调控。ABCA1功能障碍将导致动脉粥样硬化的发生、发展，与心脑血管疾病密切相关。
ABCA1, an integration member protein, can transport intracellular free cholesterol, phospholipid to extracells, combine with apo-A1 for forming HDL, getting energy by discomposing ATP. ABCA1 gene is a critical gene in cholesterol counter transport and the onset of HDL generation. The expression of ABCA1 is regulated by various factors such as LXR/RXR and cAMP at transcription and post-transcriptional level. The desfunction of ABCA1 causes the development of atbcrosclerosis, and is significantly related with cardio-cerebrovaseular disorder.
出处
《国际内分泌代谢杂志》
2008年第6期416-419,共4页
International Journal of Endocrinology and Metabolism
