乳腺癌ER、PR、Her-2表达与临床病理特征

Relationship between the expression of ER,PR,Her-2 in breast cancer and its clinical pathological features

目的探讨乳腺癌ER、PR、Her-2表达与临床病理特征的相关性。方法采用回顾性分析,统计383例乳腺癌患者ER、PR、Her-2的表达;分析ER、PR、Her-2表达的相关性;及其与乳腺癌临床病理特征的关系。结果①ER、PR、Her-2阳性率分别为60.4%、64.1%、17.2%。②ER与PR表达呈正相关;ER、PR分别与Her-2表达负相关;Her-2与ER、PR共同表达呈负相关(P<0.01)。③浸润性非特殊癌、浸润性特殊癌、非浸润癌之间ER、PR表达具有统计学差异;肿瘤大小与Her-2表达呈正相关;而且淋巴结转移数量增多,Her-2表达增高。结论①乳腺癌的ER、PR、Her-2表达之间存在相关性;②乳腺癌ER、PR、Her-2表达与病理类型、肿瘤大小、淋巴结转移数目及临床分期密切相关。

Objective To investigate the relationship between the expression of ER,PR, Her-2 in breast cancer tissue and its clinical pathological features. Methods Examined and calculated the protein expression of ER, PR, Her-2 in breast cancer tissue of 383 cases;analyzed the relationship of those three kind proteins, and also with their clinical pathological features of breast cancer. Resuits ①the positive expression of ER,PR and Her-2 is 60.4% ,64.1% and 17.2% respectively;②a positive correlation between ER and PR was observed, as well as there is a negative correlation in expression of Her - 2 with ER, PR protein respectively, with also both of them（ P 〈 0.01） . ③There is a significantly difference in the expression of ER and PR protein between Noninvasive and Invasive Breast Cancer; it was shown that the Her-2 expression was up-regulated with a increased size of tumor and number of lymphon- ode in metastasis cases. Conclusion ①There is a relationship between the protein expression of ER, PR and Her-2 ; ②and those relationships were observed clearly on pathological type,tumor size,number of lymphonode and clinical stage in breast cancer tissue also.