孤立性肺结节CT灌注成像扫描技术及诊断的探讨

To evaluate the solitary pulmonary nodules of CT perfusion imaging

目的探讨孤立性肺结节CT灌注成像技术的应用。方法利用美国GE公司的Hispeed CT 16排螺旋CT灌注扫描技术对51例孤立性肺结节(Solitary pulmonary nodule,SPN)患者病变良恶性的鉴别。结果良恶性结节灌注后具有不同的血流量(Blood flow,BF)、血容量(Blood volume,BV)、平均通过时间(Mean transit time,MTT)和表面通透性(Per-meablity surface,PS)。良恶性结节的各项灌注参数之间存在显著性差异(P<0.05),恶性结节的BV、MTT、PS均高于炎性结节,存在显著性差异(P<0.05),而BF无差异性(P>0.05),而炎性结节的BF、BV、MTT、PS均高于良性结节,均存在显著性差异(P<0.05)。结论孤立性肺结节CT灌注成像技术在临床正确诊断结节性质及做出恰当治疗措施方面显示出了重大的优越性。

Objeetive To evaluate the solitary pulmonary nodules of CT perfusion imaging.Methods To analyse the parameters of CT perfusion imaging for 51 solitary pulmonary nodules by using High-resolution multi-slice spiral CT of GE, to analyse the timedensity curve（TDC） pattern and the enhancement of the nodule at the same time. Results There are significant differences among malignant pulmonary nodules, inflammatory nodules and benign nodules in the peffusion parameters, which is statistically significant （ P 〈 0.05）. The BV,MTT、PS of malignant nodules are higher than ones of inflammatory nodules,in which there is a significant difference （ P 〈 0.05）, while the BF is not （ P 〉 0.05 ）. And the BF, BV, MTT, PS of inflammatory nodules are all higher than those of benign nodules, in which there is a significant difference （ P 〈 0.05 ）. Conclusion Multi-slice CT perfusion imaging can not only provide precise anatomic structure and morphology information but also provide hemodynamic information, so CT perfusion imging offers and applicable diagnostic method for the differential diagnosis of SPN.