摘要
目的研究胃癌组织中P27kip1蛋白的表达及其与胃癌临床生物学行为的关系。方法采用免疫组织化学方法(SP法)检测胃癌组织和正常胃粘膜中P27kip1蛋白的表达。结果P27kip1蛋白阳性表达率在胃癌中(38%)显著低于正常胃粘膜(100%)(P<0.01);P27kip1蛋白表达与胃癌患者性别、年龄、肿瘤发生部位、大小及大体分型均无关(P>0.05)。P27kip1蛋白表达与胃癌分化程度、浸润深度、淋巴结转移、PTNM分期及术后5年生存率相关(P<0.05或P<0.01)。结论P27kip1蛋白的异常表达参与了胃癌的发生、发展。
Objective To study the expression of P27^kip1 in gastric carcinoma, and the correlations between the expression and the clinical biological behavior of gastric carcinoma. Methods To examining the expression of P27^kip1 in normal gastric mucosa and gastric carcinoma by immunohistochemistry method （SP method）. Results The expression of P27^kip1 in gastric carcinoma is lower significantly than that in normal gastric mucosa（ P 〈 0.01）, In the gastric carcinoma, the expression of P27^kip1 correlate with the differentiation, invasive depth, lymph node metastasis, FI＇NM stages and 5-year survival rate （ P 〈 0.01 or P 〈 0.05）, but not with patient＇s sex, age and the tumor location, size, gross type（ P 〉 0.05）. Conclusion The abnormal expression of P27^kip1 participate in the genesis and development of gastric carcinoma.
出处
《中国实验诊断学》
2008年第11期1407-1410,共4页
Chinese Journal of Laboratory Diagnosis
