运用功能核磁共振成像观察针刺外关穴捻针状态脑区的激活

The Activation of Cerebral Areas under the State of Twirling in Waiguan Point(SJ5) by the Scan of fMRI

目的在"腧穴特异性-脑相关"假说的指导下,开展外关穴特异性的fMRI脑功能成像研究,进一步探讨外关穴功效主治与脑区激活之间的联系。方法针刺6名健康志愿者右侧外关穴,采用Block设计,针刺得气后捻转30 s后停止捻针30 s,重复6次,同时利用功能性核磁共振成像(fMRI BOLD)技术进行全脑扫描,利用统计参数图(statistical parametricmapping,SPM2)软件包处理图像。结果针刺右侧外关穴捻针状态,左右脑半球、左右小脑均有不同程度的激活,其中,左脑激活的区域相对集中在额下回、颞下回、顶下小叶和小脑,右脑激活的区域相对集中在额下回、颞上回、颞中回、顶下小叶、岛叶、边缘叶、脑干和小脑。结论运用fMRI脑功能成像技术观察到,针刺外关穴捻针状态下,不同功能脑区有着相对特异的激活,这些脑区与针刺外关穴的功效密切相关,初步表明针刺外关穴的信号在脑区有着相对特异的响应。

Objective Based on the hypothesis of ＂ specific acupoint-brain relationship＂, we observed 6 healthy volunteers by fMRI brain scan during needling in Waiguan （SJ5） and tried to analyze the relationship between needling SJ5 and the activation of cerebral functional areas. Methods The right side SJ5 of 6 healthy volunteers were needled as twirling 30s and 30 non - stimulating altermatively for 6 times under the design of Block. Meanwhile, scanned the whole brain by fMR BOLD technology. The cerebral functional changes were analyzed with SPM2 software. Results During puncturing SJ5, Brodmann area （BA）13, 22, 37, 40, 44, 45 and 47, right Hippocampus, Amygdala and Substantia nigra, and bilateral cerebellum could be activated. Conclusion Needling in SJ5 can result in a certain activiation in different cerebral functional areas proved by the technology of fMRI, which indicated that there was a certain relationship between needling SJ5 and the brain.