圈养大熊猫麻疹病毒易感性流行病学调查(英文)

Seroprevalence of susceptibility to morbillivirus infection on giant panda in captivity

成都大熊猫繁育研究基地对圈养的7只8～21岁的大熊猫血清犬瘟热病毒(CDV)中和抗体滴度进行了测定。结果显示,尽管这些大熊猫自2003年起每年接受2次CDV弱毒疫苗接种,该弱毒疫苗是由未知家犬犬瘟热病毒株制作的,大熊猫血清犬瘟热病毒中和抗体滴度却在2×到256×的较大范围内(平价值=16)波动。通常单次的麻疹病毒弱毒疫苗注射足以导致宿主产生相应的稳定的免疫反应,在大熊猫上抗犬瘟热中和抗体变化幅度较大提示在宿主与疫苗的关系中存在某种程度的不足。

Canine distemper virus （CDV） neutralizing antibody （NT） titer was examined against the sera from 7 giant pandas aged between 8 to 21 years housed at Chengdu Research Base of Giant Panda Breeding,China. Anti CDV NT titer against the Onderstepoort strain showed a wide range from × 2 to × 256 （median= 16）, even though the animals had been receiving an attenuated live vaccine made from an anonymous domestic CDV strain twice a year since 2003. A single administration of attenuated morbillivirus antigen often be enough to give corresponding host a steady immunogenicity. Anti CDV-NT variation in the giant panda suggests some deficiency in the relationship between the vaccine and the host.