肝硬化患者血清钠及胆汁酸检测的临床意义

Significance of determination of serum sodium and total bile acid in patients with cirrhosis

目的:探讨血清钠、血清总胆汁酸(TBA)在肝硬化患者中的变化,揭示其与预后的关系。方法:检测61例肝硬化患者的血清钠、TBA以及白蛋白、胆红素、凝血酶原时间及彩色多普勒超声。结果:随着肝硬化失代偿程度的加重,血清钠逐渐降低,TBA逐渐升高,在肝功能Ch ild-Pugh分级间比较,差异有统计学意义(P<0.01)。结论:血清钠下降,TBA升高与肝硬化病情严重程度密切相关,检测血钠、TBA对判断肝硬化患者病情、转归及预后有重要参考意义,可作为反映肝硬化失代偿患者肝损害程度的辅助生化指标之一。

Objective To study the relatiotiship between serum sodium, serum total bile acid （TBA） and Child -Pughg grade in patients with liver cirrhosis. Method The levels of serum sodium, TBA, albumin, biiirubin, prothrombin time, and B - ultrasound were measured in 61 patients with liver cirrhosis. Results It was showed that serum sodium was dropped, TBA was increased gradually with the degree of clinical fiver cirrhosis deteriorated. Conclusion There are closely relationship between serum sodium and Child - Pugh＇s grade, TBA and Child - Pugh＇s grade. Measuring the concentration of serum sodium and TBA are of important reference value in predicting the degrees and prognosis of liver cirrhosis.