门冬氨酸鸟氨酸治疗重度黄疸性肝炎疗效观察

Effect observation of L-ornithine-L-aspartate in the management of severe icteric viral hepatitis

目的:观察门冬氨酸鸟氨酸治疗重度黄疸性肝炎临床疗效。方法:把72例重度黄疸性肝炎随机分为两组,分别接受4周的门冬氨酸鸟氨酸及门冬氨酸钾镁治疗,检测患者治疗前后血清总胆红素。结果:4周治疗结束时降低血清总胆红素的有效率,门冬氨酸鸟氨酸组高于门冬氨酸钾镁组,两组比较差异有统计学意义(P<0.01)。结论:门冬氨酸鸟氨酸(瑞甘)对重度黄疸肝炎有明确疗效。

Objective To observe the effect of L - ornithine - L - aspartate in the management of severe icteric viral hepatitis. Method Seventy -two patients with severe icteric viral hepatitis were randomly divided into two groups, received 4 weeks＇ treatment with travenous L - ornithine - L - aspartate, potassium magnesium aspartate, respectively. The serum total bilirubin were tested in all patients at the onset and the end of treatment. Results The effective rates of lowering serum total bilirubin were respectively in the group with L - ornithine - L -aspartate than in the group with potassium magnesium （P 〈0.01 ）. Conclusion The levels of serum total bilirubin are able to be effectively lowered in the patients with severe ieterie viral hepatitis by the management of intravenous L - ornlthine - L - aspartate.