摘要
目的通过单因素及多因素分析，评估甲状腺结节患者发生甲状腺癌的危险因素。方法用单因素分析及多因素Logistic回归法分析2003年1月～2007年12月因甲状腺结节在我科行手术治疗，临床资料均完整的590例，（683侧）的性别、年龄、B超表现（结节多少、大小、回声情况、有无钙化、血供情况、有无颈淋巴结肿大）与甲状腺结节良恶性之间的关系。结果683侧中男性147侧（24．5％），有151侧年龄I〉45岁（22．1％），病理证实甲状腺恶性肿瘤83侧（12．2％）。单因素分析结果：B超表现为低回声、有钙化、伴颈部淋巴结肿大与甲状腺恶性肿瘤密切相关（P〈0．01）；高龄（≥45岁）、B超表现为多（单）发结节、血流丰富与甲状腺恶性肿瘤相关（P〈0．05）。多因素分析发现：高龄（≥45岁）、B超表现为低回声、有钙化、有颈部淋巴结肿大为甲状腺癌的危险因素（P〈0．05）。结论高龄（≥45岁）、B超表现为低回声、有钙化、有颈部淋巴结肿大为甲状腺癌的危险因素。
Objective To investigate the malignancy possible factors in patients with solitary and multiple thyroid nodules. Methods 590 cases were obtained from the patients operated on from Jun. 2003 to Nov. 2007. Patients＇ gender, age and the ultrasonographic characteristics of their thyroid nodules were analyzed, including single vs multiply, size, echogenicity, intrathyroidal calcification, internal vascularity and cervical tumescent lymph nodes. Individual features and combinations of features were analyzed for their correlation with benign or malignant disease. Results The result of the logistic procedure showed that the possibl factors of thyroid carcinoma were elder age （≥45） , hypoeehogenecity, intrathyroidal calcification and cervical tumescent lymph nodes （p 〈 0.05 ）. There was no correlation between gender, the quantity of thyroid nodules, size, internal vascularity and thyroid carcinoma. Conclusion The possible factors of thyroid carcinoma would be elder age （≥45）, hypoechogenecity, intrathyroidal calcification and cervical tumescent lymph nodes.
