益气化痰通络方治疗急性脑栓塞疗效观察

Clinical Observation of"Yiqi Huatan Tongluo Decoction"in Treating Acute Cerebral Embolism

目的探讨益气化痰通络方治疗急性脑栓塞的临床疗效。方法选发病在72h以内的急性脑栓塞患者78例,随机分为治疗组和对照组各39例;对照组采用常规治疗,治疗组在此基础上加服中药益气化痰通络方,两组疗程均为15d。观察两组临床疗效和治疗前后神经功能缺损评分、血脂及血液流变学变化情况。结果治疗组、对照组总有效率分别为87.1%和79.5%,组间疗效比较,差异无统计学意义(P>0.05);治疗组治疗前后神经功能缺损评分、血液流变学和血脂指标比较,差异均有统计学意义(P<0.05,P<0.01);治疗后组间比较,神经功能缺损评分、纤维蛋白原和总胆固醇差异有统计学意义(P<0.05,P<0.01)。结论益气化痰通络方结合常规治疗可提高急性脑栓塞的临床疗效,明显改善神经功能缺损评分、血液流变学和血脂指标,值得临床推广应用。

Objective To observe the clinical effects of ＂Yiqi Huatan Tongluo Decoction＂ in the treatment of acute cerebral embolism. Methods Seventy-eight cases of acute cerebral embolism were divided randomly into treatment group（39 cases） and control group（36 cases）. The treatment group was given ＂Yiqi Huatan Tongluo Decoction＂ besides conventional therapy, and the control group was treated only with conventional therapy. The curative effect was assessed in terms of nerve deficit score, the indexes of blood fat and hemorrheology. Results The total effective rate was 87.1% in the treatment group and 79.5% in the control group, P〉0.05; the nerve deficit score and indexes of hemorheology and blood-fat in the treatment group showed significant differences （P〈0.05, P〈0.01）after treatment in treatment group; at the end of the trial, the nerve deficit score, fibrinogen and total cholesterol in the two groups were significantly different（P〈0.05, P〈0.01）. Conclusion ＂Yiqi Huatan Tongluo Decoction＂ can help conventional therapy to enhance clinical effects and improve nerve deficit score, hemorheology and blood fat.