用ICP-MS对不同厂家六味地黄丸(胶囊)进行元素分析

Elements analyses with ICP-MS in Liuwei Dihuang pills(capsules)from different manufactures measured

目的:测定全国不同厂家六味地黄丸(胶囊)中15种元素的含量,探讨不同剂型中无机元素对六味地黄丸(胶囊)质量的影响。方法:用微波消解样品,电感耦合等离子体质谱(ICP-MS)法同时测定15种元素,用国家标准物质茶树叶(GBW08513)以及用加样回收实验以验证方法的准确度。结果:通过对5种重金属元素和10种人体必需元素与微量元素日摄入量进行聚类分析,将不同剂型分成2类,水蜜丸、大蜜丸分成一类,胶囊和浓缩丸分成一类。结论:剂型之间元素含量存在差异。该方法简便、快速、准确、可靠.

Objective：To determine the contents of 15 elements in Liuwei Dihuang pills （capsules）from different manufactures, and to discusses the quality influence of inorganic elements to the Liuwei Dihuang pills （capsules） of the different dosage-forms. Method：The ICP/MS wat to determine the 15 elements in the sample,which were digested with microwave digestion system. The accuracy of the method was validated by measuring the leaves tea reference material（GBW08513 ）. Results： The result of cluster analysis showed that it was divided into two different forms, water- honeyed pills, the big hineyed pills divided into a categoriy, and the capsules and concentrated pills divided into another categoriy. Conclusion：The elements daily intake content is different among various dosage - forms. The method is simple ,rapid, accurate and reliable.