广西毛南族女性甲状旁腺素和降钙素水平变化情况的研究

Study on the changes of PTH and calcitonin in the Maonan nationality women in Guangxi

目的观察广西毛南族女性血清甲状旁腺素（PTH）和降钙素（CT）水平的变化规律，探讨其在骨质疏松症中的影响。方法用放射免疫分析法测定了171例不同年龄组的毛南族女性血清中PTH、CT含量，观察不同年龄组的变化规律。结果P1H水平随着年龄的增长逐渐增高（P〈0．01），在40～50岁（绝经期）增幅最快（P〈0．01）；在20岁以后、40岁前CT变化不大（P〉0．05），50岁以后则有逐渐降低趋势（P〈0．01），绝经后（50岁）降幅最快（P〈0．01）。结论毛南族女性绝经后雌激素水平的降低，拮抗PTH和增强CT的能力也相应降低，这是发生绝经后骨质疏松的主要原因。

Objective To investigate the effect of serum parathyroid hormone （PTH） and calcitonin on esteoporosis in the Maonan nationality women in Guangxi. Methods Detected the serum PTH and caleitonin in 171 people from Maonan nationallity wemon in different age groups by radioimmunoassay and observed their variation. Results The age increased the level of PTH gradually increased （P 〈 0.01 ）, and the fastest increament was in menopause （ age from 40 to 50） （P 〈 0.01 ）. The level of calcitonin was no significant between the year 20 and 40 （P 〉0.05） ,but it showed the trend decreasing gradually after 50 years （P 〈0.01 ） ,and it reached the fastest amplitude reduction in postmenopause （50 years） （P 〈0.01 ）. Conclusion The estrogen level decreased in the Maonan nationality women after menopause with the decrease of antagonistic PTH and enhanced calcitonin accordingly,which was the main reasons for postmenopausal esteoporosis.