氟西汀合并尼莫地平治疗脑卒中后抑郁76例的临床研究被引量：7

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摘要目的观察氟西汀合并尼莫地平治疗脑卒中后抑郁的疗效。方法76例脑卒中抑郁患者随机分为两组,每组38例。实验组接受氟西汀合并尼莫地平治疗;对照组接受氟西汀合并安慰剂治疗,采用汉密顿汉密尔顿抑郁量表(HAMD)评定抑郁症状,改良爱丁堡斯堪的那维亚评分量表(MESS)评定神经功能缺损程度,分别在治疗第4周及第8周对两组进行HAMD及MESS评分。结果在第4周及第8周末HAMD评分实验组分别为(13.4±1.6)分、(6.8±1.4)分;低于对照组的(15.7±2.1)分和(8.7±2.3)分;MESS评分实验组分别为(8.5±3.8)分、(6.1±2.2)分,对照组分别为(13.2±4.1)分和(10.0±3.1)分,差异均有统计学意义(P<0.05)。结论氟西汀合并尼莫地平能增强抗抑郁效果,且有利于神经功能的改善。

作者张为覃少东韦奇黄澄

机构地区广西壮族自治区江滨医院神经内科一区

出处《广西医学》 CAS 2008年第12期1859-1860,共2页 Guangxi Medical Journal

关键词脑卒中抑郁症后遗症氟西汀尼莫地平

分类号 R743 [医药卫生—神经病学与精神病学] R971.43 [医药卫生—药品]

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1Robinson RG. Post-stroke depression prevalence, diagnosis, treatment, and disease progression [ J ]. Biolpsychiatry ,2003,54 (3) :376 - 387.
2Taragano FE, Allegri R, Vicario A, et al. A double blind, randomized clinical trial assessing the efficacy and safety of augmenting standard antidepressant therapy with nimodipine in the treatment of vascular depression[J]. Int J Geriatr psychiatry,2001,16(3) :254 -260.
3周红.百优解对卒中后抑郁状态及神经功能恢复作用的临床观察[J].广西医学,2002,24(5):621-623. 被引量：1
4Alexopoulos GS, Meyers BS, Young RC, et al. vascular depression hypothesis[ J]. Arch J Psychiatry,1997,54(10) :915 -922.
5Ghika-Schmid F, Bogonsslavsky J. Affective disorders following stroke [J]. Eur Neurol,1997,38(2) :75 -81.
6Wiart L,Petit H,Joseph PA,et al. Fluoxetine in early poststroke depression: a double-blind placebo-controlled study[J]. Stroke,2000,31 (3) :1 829 -1 832.
7Krishnan Hays JG, Tupter LA, et al. Clinical and phenomenotogical comparison of late-onset and early-onset depression[ J ]. Am J Phgchiatry, 1995,152 (3) :785 - 788.
8李文迁,陈志宏,李德香.西酞普兰合并尼莫地平治疗血管性抑郁症68例的疗效[J].中国新药与临床杂志,2006,25(7):504-507. 被引量：4

二级参考文献16

1李文迁.西酞普兰治疗肠易激综合征46例[J].中国新药与临床杂志,2005,24(7):529-531. 被引量：4
2孟家眉.对脑卒中临床研究工作的建议[J].中华神经精神科杂志,1988,21:57-58.
3孙阳（译）.氟西汀与麦普替林对脑卒中后偏瘫康复的疗效[J].国外医学：脑血管疾病分册,1996,4(4):378-378.
4ANDERSON DN. Treating depression in old age: the reasons to be positive[J]. Age Aging, 2001,30 ( 1 ) : 13 - 17.
5TARAGANO FE,ALLEGRI R,VICARIO A, et al. A double blind,randomized clinical trial assessing the efficacy and safety of augmenting standard antidepressant therapy with nimodipine in the treatment of "vascular depression" [J]. Int J Geriatr Psychiatry, 2001,16 (3) : 254-260.
6ALEXOPOULOS GS, MEYERS BS,YOUNG RC, et ol. "Vascular depression" hypothesis[J]. Arch Gen Psychiatry, 1997,54 (10) :915-922.
7ALEXOPOULOS GS,MEYERS BS,YOUNG RC, et al. Clinically defined vascular depression[J]. Am J Psychiatry, 1997,154 (4) :562-565.
8ALEXOPOULOS GS. Role of executive function in late-life depression[J]. J Clin Psychiatry,2003,64(1) : 18-23.
9NEUMEISTER A. Tryptophan depletion, serotonin, and depression: where do we stand?[J]. Psychopharmacol Bull,2003,37(4) :99-115.
10TIMMERMANN DB, LUND TM, BELHAGA B, et al. Localization and pharmacological characterization of vohage dependent calcium channels in cultured neocortical neurons [J]. Int J Dev Neurosci,2001,19(1) : 1-10.