摘要
目的:建立家兔高脂血症模型,探讨脂康方剂降低血脂、抑制动脉粥样硬化发展及调节机体免疫功能的机理。方法:1)建立高脂血症家兔模型;2)观察主动脉病理改变;3)检测C反应蛋白、可溶性细胞间黏附分子-1的水平。结果:1)成功建立高脂血症家兔模型;2)通过对血脂水平、C反应蛋白、可溶性细胞间黏附分子-1水平的检测,发现脂康方剂可有效降低血脂水平,调节动脉粥样硬化家兔C反应蛋白、可溶性细胞间黏附分子-1的水平。结论:脂康方剂可有效降低高脂血症家兔血脂水平,并具有显著的抗炎作用。
Objective ： To explore the mechanism of immune - mediating of Zhikang Pill in decreasing blood lipid to control the development of atherosclerosis by setting up hyperlipemia models of New Zealand rabbits. Methods ： 1 ） Set up hyperlipemia models of New Zealand rabbits ; 2） Observe the pathological changes in endarterium ;3 ） Study the effects of Zhi Kang Pill by detecting the levels of C - reactive protein and soluble intercellular adhesion molecule - 1 through ELISA. Results ： 1 ） Hyperlipidemia models were successfully established by using high - fat diet in New Zealand rabbits ; 2 ） Zhi Kang Pill can effectively reduce blood lipid level and regulate the levels of C - reactive protein and soluble intercellular adhesion molecule - 1, Conclusion ：Zhi Kang Pill can effectively reduce the level of blood lipid in rabbit and has significant anti - inflammatory effects.
出处
《世界中医药》
CAS
2008年第6期368-369,共2页
World Chinese Medicine
