摘要
应用原子吸收光谱法测定血药浓度，对10例中晚期胃肠癌患者经腹股沟结灌注顺铂的药代动力学进行初步研究。结果显示总铂在血浆中的药代动力学模式为二室模型。经淋巴结途径给药后血浆总铂浓度迅速升高，在15～20min之内达到峰值，随即缓慢消除下降。血浆分布半衰期（t1／2a）为0.185h，血浆消除半衰期（t1／2β）为6.944h，提示从腹腔沟淋巴结途径给药肿瘤组织可较多摄取顺铂。
Platinum concentrations in plasma were measured by atomic absorption spectrometry. The pharmacokinetic study in 10 patients with middle or advanced stage gastroenteral carcinomas,who received cisplatin via inguinal intralymphnode was carried out.The initial results showed that the pharmacokinetics of total platinum in plasma assumed two-compartment mode. The total platinum concentrations in plasma increased rapidly following intralymphnode administration,reached the peak within 15-20 minutes,and then subsided slowly. The platinum distribution half-life time in plasma(T1 /2α)was 0. 485 hr.,and elimination one(T1/2β) 6. 944hr. It is indicated that the tumour tissue might be able to intake more cisplatins after intralymphnode administration inguinally.
出处
《海峡药学》
1997年第1期54-55,共2页
Strait Pharmaceutical Journal
