培菲康与匹维溴铵治疗腹泻型肠易激综合征疗效对比研究

Comparison of Cure Effect of Peifeikang and Pinaverium Bromide on Diarrhea Irritable Bowel Syndrome(IBS)

[目的]探讨肠易激综合征有效治疗途径。[方法]腹泻型肠易激综合征患者98例随机分为3组,培菲康加匹维溴胺(联合治疗)组32例;匹维溴胺组30例,培菲康组36例。[结果]联合治疗组和匹溴维胺组与培菲康组相比,腹痛改善显著(P<0.05)。联合治疗组与匹溴维胺组间差异无统计学意义(P>0.05),联合治疗组与匹溴维胺组相比,腹胀改善显著(P<0.05);匹溴维胺组和培菲康组间差异无统计学意(P>0.05)。培菲康组在改善腹泻方面比匹溴维胺组更有效(P<0.05)。[结论]匹溴维胺联合应用培菲康治疗腹泻型肠易激综合征对患者腹痛、腹泻、腹胀症状改善显著,联用培菲康可增强匹溴维胺的疗效。

[Objective]To discuss the effective method for IBS. [Method]Diarrhea IBS 98 cases were divided into 3 groups, one group 32 cases treated with Peifeikang and Pinaverium Bromide（combination treatment）, one group 30 with Pinaverium Bromide, another group 36 Peifeikang. [Result]Comparing combination group and Pinaverium Bromide group with Peifeikang group, the abdomen pain was relieved markedly（P〈0.05） ; there＇s no statistical difference between combination group and Pinaverium Bro- mide group （P〉0.05）; comparing combination group with Pinaverium Bromide group, the distension was obviously relieved（P 〈0. 05） ;there＇s no statistical difference between Pinaverium Bromide group and Peifeikang group（P〉 0.05）. But Peifeikang group was more effective on relieving diarrhea compared with Pinaverium Bromide group （P〈0.05）. [Conclusion] Pinaverium Bromide combined with Peifeikang treating diarrhea IBS can markedly relieve patients＇ symptoms of abdomen pain, diarrhea and distention, and reinforce the cure effect.