胰腺癌患者血清肿瘤标志物的检测及其临床意义

Assay and clinical significance of serum tumor markers in diagnosis of pancreatic carcinoma

目的观察胰腺癌患者血清肿瘤标志物的表达，分析其对胰腺癌诊断与预后判断的价值。方法采用化学发光法检测95例胰腺癌患者AFP、CEA、CA199、CA125和酶联免疫吸附方法检测CA242，并与80例其他系统恶性肿瘤患者和65例良性疾病患者作比较，同时对不同TNM分期的胰腺癌的五个指标比较。结果5种肿瘤标志物中CA199、CA125、CA242对胰腺癌的诊断有较高价值，其中CA199价值最高，灵敏度和特异度分别为76．2％和74．8％。CA199、CA242、CA125随着胰腺癌的病程进展而逐步升高。结论血清CA199、C242和CA125的检测对胰腺癌的诊断和判断预后有价值。

Objective To investigate the expression of serum tumor markers in pancreatic carcinoma and to assess the value of serum tumor markers in the diagnosis and prognosis of pancreatic carcinoma. Methods Five serum tumor markers including AFP, CEA, CA199, CA125 and CA242 were detected in 95 patients with pancreatic carcinoma by chemi-luminescence immunoassay （CLI） and enzyme linked immunosorbent assay （ELISA）, 80 patients with other malignant tumor and 65 patients with benign disease served as controls. Five tumor markers in pancreatic carcinoma diagnosis for TNM staging were compared. The value of tumor markers for prognosis was analyzed. Results Among these 5 kinds of tumor marker, CA199, CA125, CA242 were valuable in diagnosis of pancreatic carcinoma, and CA199 was the most valuable one, whose sensitivity and specificity were 76.2 % and 74.8 % respectively. CA199, CA125, CA242 were increased with progression of pancreatic carcinoma. Conclusion Serum CA199, CA125 and CA242 are the preferred tumor markers to be used in the diagnosis and prognosis of pancreatic carcinoma.