γ-氨基丁酸能受体在嗅觉编码中作用的仿真研究

Simulation of GABA receptor on olfactory coding

目的在建立蝗虫触角叶仿真模型的基础上,通过改变γ-氨基丁酸能(GABA,抑制性神经递质)突触电流的仿真参数,研究抑制性连接对嗅觉时空编码的影响。方法利用Hodgkin-Huxley方程,建立离子电流模型的常微分方程,运用MATLAB软件进行求解,计算每个兴奋性神经元(PN)动作电位相对于局部场电位峰值的相位,重复仿真计算20次,显示结果用黑点表示。结果阻断GABA突触连接会影响PNs的响应模式,具体表现在与局部场电压(LFP)保持同步的PNs的个数将会发生变化。结论进一步认识同步振荡现象和突触连接在嗅觉识别中起的关键作用。

Objective To investigate the influence of inhibitory connections on the spatiotemporal olfactory coding,through changing parameters of GABAergic （GABA,γ-aminobutyric acid） synaptie currents based on establishing a model of locust antennal lobe. Methods The ordinary differential equations of ion current models were established by means of Hodgkin- Huxley equations and solved by MATLAB software. The phases of the action potentials of each excitatory projection neuron （PN） relative to the maximum of the corresponding field potential were calculated and plotted with black dots and these calculation were repeated 20 times. Results The study was showed that response patterns of PNs could be affected by blocking GABAergic synapses leading to a change in the number of PNs synchronized with the local field potential. Conclusion The results are helpful in study on the oscillatory synchronization and synaptic connection which play an important role in olfactory recognition.