PPARγ及VEGF在胃癌组织中的表达及临床相关性

The Expression and Clinical Significance of PPARγ and VEGF in Gastric Cancer Tissues

目的:研究过氧化酶增殖因子活化受体和血管内皮生长因子在胃癌组织中的表达及其相关性。方法:采用免疫组化法检测40例胃癌手术中的PPARγ、VEGF表达,同时选取相同病例的癌旁组织、癌旁正常组织作为对照。结果:免疫组化提示PPARγ阳性率在胃癌中是72.5%,癌旁组织中是25%,癌旁正常组织中是17.5%,三者表达差异有统计学意义;VEGF阳性率在胃癌中是75%,癌旁组织中是40%,癌旁正常组织中是10%,三者表达差异有统计学意义;PPARγ的蛋白表达与VEGF表达有关(r=0.388,P=0.013);结论:PPARγ可能影响胃癌新生血管的形成。

Objective：To study the significance of expression of peroxisome proliferator-activated receptor gamma（PPARγ）and vascular endothelial growth factor（VEGF）in gastric carcinoma as well as their correlation.Methods：The tissue chips of 40 cases of gastric cancer tissues were adopted by the immunohistochemical methods compared with paired adjacent mucosa and normal mucosa for 40 same cases.Results：The positive rate of PPARγ protein was significantly higher in gastric carcinoma of 40 cases（72.5%）than in their paired adjacent mucosa of 40 cases（25%）and normal mucosa of 40 cases（17.5%）,PPARγ espression was well correlated with VEGF（r=0.388,P=0.013）in protein level.Conclusion：The results suggestcd that there was a closely relationship between PPARγ and VEGF and PPARγ might be the effective angiogenesis for gastric cancer.