急性脑梗死患者血清中对氧磷酶活性的研究

Serum Paraoxonase Activity of Patients with Acute Cerebral Infarction

目的:探讨血清中对氧磷酶活性与急性脑梗死之间的关系。方法:急性脑梗死患者40例,健康体检者40例,取清晨空腹静脉血4 mL,分别测定血清对氧磷酶(paraoxonase,PON1)活性及血浆高密度脂蛋白(highdensity lipoprotein,HDL)浓度,以PON1活性及酶活性/HDL为观察指标,采用相关方法进行统计分析。结果:急性脑梗死组与健康对照组相比,血清对氧磷酶活性显著降低(P<0.05)。两组受试者血浆高密度脂蛋白浓度差别无统计学意义(P>0.05);急性脑梗死组与对照组比较,酶活性/HDL也有显著降低(P<0.05)。急性脑梗死组中,合并糖尿病的患者血清对氧磷酶活性较无糖尿病合并症患者明显降低(P<0.05)。结论:血清对氧磷酶活性降低与急性脑梗死尤其是合并糖尿病者关系密切。血清对氧磷酶活性降低可能是急性脑梗死的一个独立危险因素,我们的研究为急性脑梗死的发病机制的探讨、诊断和治疗本病提供了理论依据。

Objective：To explore the relationship between serum paraoxonase（PON1） activity and acute cerebral infarction.Methods：In these two groups,each with 40 individuals,one is the acute cerebral infarction group,the other is the healthy control group.4 mL of blood from all individuals were taken from cubital vein on the condition of an empty stomach,PON11 activity and HDL were tested individuals.Results：Serum PON1 activity had a significant fall in the patients of acute cerebral infarction group compared with individuals of the healthy control group（P〈0.05）.HDL of both two experimental groups didn＇t appeared a significant difference（P〉0.05）.PON1 Activity/HDL in the acute cerebral infarction group compared to that in the control group had still a significant difference.In the acute cerebral infarction group,PON1 activity of the patients with the diabetes complication had a significant difference compared to the patients with no complication（P〈0.05）.Conclusion：The decrease of PON1 activity is relative to the acute cerebral infarction,especially,to the patient with the diabetes complication.Decrease of PON1 activity can be a independent dangerous factor for the acute cerebral infarction.Our study established a theoretical foundation for the mechanics,diagnosis and treatment of the acute cerebral inarction.