代谢综合征患者脂蛋白相关磷脂酶A2活性变化的特征

The Characteristics of Lipoprotein-associated Phospholipase A2 Activity in the Metabolic Syndrome

目的:脂蛋白相关磷脂酶A2是一项新的与低水平炎症反应有关的炎性标志物,该研究通过检测代谢综合征患者中该酶水平的变化,探讨代谢综合征的炎症反应机制。方法:采用病例-对照研究,健康对照组与代谢综合征组各65例,均为男性。测定两组人群血浆中脂蛋白相关磷脂酶A2活性。结果:与健康对照组相比,代谢综合征患者血浆中脂蛋白相关磷脂酶A2活性较高(76.98比60.58μmol/L.min,P<0.001)。结论:脂蛋白相关磷脂酶A2活性在代谢综合征患者中升高,表现出低水平的炎症反应。

Objective：Lipoprotein-associated phospholipase A2（Lp-PLA2） is a novel inflammation marker associated with the low-grade inflammatory action.The objective of this study is to investigate its changes in the metabolic syndrome（MS）.Methods：A case-control study was used including 65 cases and 65 controls and all were male.The activity of plasma Lp-PLA2 was measured.Results：Compared to the control group,the total plasma Lp-PLA2 activity（76.98 vs.60.58 μmol/L·min,P〈0.001） was higher in the MS group than in the control group.Conclusion：The activity of Lp-PLA2 is higher in the MS patients,indicating that the low-grade inflammation may exist in the MS patients.