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Klotho基因及其表达产物与心血管系统相关研究

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作者 侯言彬 郑智奇 汪汉 邓珏琳
机构地区 四川大学华西医院老年病科 四川省巴中市骨科医院门诊部
出处 《华西医学》 CAS 2008年第2期394-395,共2页 West China Medical Journal
基金 自然科学基金资助项目(No.0670850)
关键词 KLOTHO基因 心血管系统 表达产物 KLOTHO基因 正常小鼠 单基因突变 转基因小鼠 相关症状
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献34

  • 1Kuro-o M,Matsumura Y,Aizawa H,et al.Mutation of the mouse klotho gene leads to a syndrome resembling ageing[J].Nature,1997,390(6655):45-51.
  • 2Masuda H,Chikuda H,Suga T,et al.Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice[J].Mech Ageing Dev,2005,126(12):1274-1283.
  • 3Kurosu H,Yamamoto M,Clark JD,et al.Suppression of aging in mice by the hormone Klotho[J].Science,2005,309(5742):1829-1833.
  • 4Matsumura Y,Aizawa H,Shiraki-Iida T,et al.Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein[J].Biochem Biophys Res Commun,1998,243(3):626-630.
  • 5Ohyama Y,Kurabayashi M,Masuda H,et al.Molecular cloning of rat klotho cDNA:markedly decreased expression of klotho by acute inflammatory stress[J].Biochem Biophys Res Commun,1998,251(3):920-925.
  • 6Shiraki-Iida T,Aizawa H,Matsumura Y,et al.Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein[J].FEBS Lett,1998,424(1-2):6-10.
  • 7肖能明,张焱明,郑权,顾军.Klotho is a serum factor related to human aging[J].Chinese Medical Journal,2004(5):742-747. 被引量：17
  • 8Mitani H,Ishizaka N,Aizawa T,et al.In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage[J].Hypertension,2002,39(4):838-843.
  • 9Aizawa H,Saito Y,Nakamura T,et al.Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats[J].Biochem Biophys Res Commun,1998,249(3):865-871.
  • 10Hamdi HK,Castellon R.A genetic variant of ACE increases cell survival:a new paradigm for biology and disease[J].Biochem Biophys Res Commun,2004,318(1):187-191.

二级参考文献12

  • 1H. Kawaguchi*,N. Manabe,H. Chikuda,K. Nakamura,M. Kuro-o.Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse[J].Cellular and Molecular Life Sciences.2000(5)
  • 2R. Nagai*,Y. Saito,Y. Ohyama,H. Aizawa,T. Suga,T. Nakamura,M. Kurabayashi,M. Kuro-o.Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases[J].Cellular and Molecular Life Sciences.2000(5)
  • 3ShirakiIidaT,AizawaH,MatsumuraY etal.Structureofthemouseklothogeneanditstwotranscriptsencodingmembraneandsecretedprotein[].FEBS Letters.1998
  • 4MianIS.Sequence structural functional andphylogeneticanalysesofthreeglycosidasefamilies[].BloodCellsMolDis.1998
  • 5ArkingDE,KrebsovaA,MacekMS etal.Associationofhumanagingwithafunctionalvariantofklotho[].Proceedings of the National Academy of Sciences of the United States of America.2002
  • 6ShirakiIidaT,IidaA,NabeshimaY etal.Improvementofmultiplepathophysiologicalphenotypesofklotho (KL/KL)micebyadenovirus mediatedexpressionoftheklothogene[].JGeneMed.2000
  • 7MitaniH,IshizakaN,AizawaT etal.InvivoklothogenetransferamelioratesangiotensinⅡ inducedrenaldamage[].Journal of Hypertension.2002
  • 8SaitoY,YamagishiT,NakamuraT etal.Klothoproteinprotectsagainstendothelialdysfunction[].Biochemical and Biophysical Research Communications.1998
  • 9KawaguchiH,ManabeN,ChikudaH etal.Cellularandmolecularmechanismoflow turnoverosteopeniaintheklotho deficientmouse[].CellMolLifeSci.2000
  • 10FukinoK,SuzukiT,SaitoY etal.Regulationofangio genesisbytheagingsuppressorgeneklotho[].Biochemical and Biophysical Research Communications.2002

共引文献16

华西医学
2008年 第2期

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