雌三醇阴道软膏预防绝经后妇女复发性尿路感染的疗效观察

Preventive effect of estrio-ointment for recurrent urethra infection in post-menopause women

目的探讨阴道内使用雌三醇软膏对绝经后妇女复发性尿路感染的预防作用。方法80例有复发性尿路感染病史的绝经后妇女随机法进入实验组和对照组。实验组40例使用雌三醇软膏,对照组40例使用安慰剂软膏,疗程6个月。结果实验组中发生尿路感染事件5例(13%)明显低于对照组31例(77.5%),且实验组患者实验过程中首次出现尿路感染复发的时间较对照组明显延后;治疗后实验组阴道分泌物检出乳酸杆菌的例数为22例,对照组无乳酸杆菌检出,两者具有显著性差异(P<0.05);实验组雌三醇软膏治疗前后阴道pH值分别平均为7.8±0.4及5.3±0.2,对照组为7.9±0.81及7.7±0.6,两组相比具有显著性差异(P<0.05)。结论阴道局部用雌三醇软膏能有效延长绝经后妇女复发性尿路感染的复发间隔时间,降低复发率,而且使用方便、安全可靠,可作为预防用药。

Objective To evaluate the preventive effect of estrio-ointment on recurrent urethral infection in postmenopause women. Methods 80 post-menopause women with recurrent urethral infection were divided into two groups randomly. 40 patients were treated with estrio-orintment in vagina as the treatment group, another 40 with placebo as the control group. The course of treatment was 6 months. Results The recurrence of urethral infection in the treatment group （5 cases） was significantly less than that in the control group （31 cases） and the first recurrence was delayed in the treatment group; 22 cases with lactobacilli test of vaginal secretion showed positive in treatment group, but no case was positive in the control group, with signficant difference between the two groups （P〈0.05）. Conclusion Local use of estrio-ointment effectively delayed the recurrent urethral infection in post-menopause women and decreased the relapse rate. To be a preventive medicine, it is convenient, safe and reliable.