原发性输卵管癌预后因素研究

Analysis of Prognostic Factors in Primary Fallopian Tube Carcinoma

目的:探讨影响原发性输卵管癌预后的因素。方法:应用单因素和多因素生存分析方法,回顾性分析我院1994年1月至2006年10月收治的有完整临床及随访资料的50例原发性输卵管癌,对其预后因素进行研究。结果:患者平均年龄56岁。总的5年生存率为38%,中位生存时间48个月。单因素分析显示,肿瘤的FIGO分期、分化程度、腹腔细胞学检查结果、术后残留灶大小、淋巴结转移情况、化疗方案均是影响该病预后的因素(均P<0·05)。应用Cox比例风险回归模型显示,FIGO分期、分化程度、术后残留灶大小、淋巴结转移情况是影响该病预后的独立因素(均P<0·05)。结论:原发性输卵管癌预后较差,理想的肿瘤细胞减灭术后辅以紫杉醇、铂类为主的化疗为延长患者生存期提供了一定的可能性。

Objective：To analyze the prognostic factors in primary fallopian tube carcinoma（PFTC）.Methods：Fifty patients with PFTC treated at our institution between January,1994 and October,2006 were retrospectively analyzed.All the patients had complete clinical data.Univariate and multivariate stastical methods were used to evaluate several factors for their prognostic impact in this disease.Results：The mean age of the patients was 56 years.The 5-year survival for the group as a whole was 38%,and the median survival was 48 months.In univariate analysis stage,grade,peritoneal cytology,residual disease after surgery,lymph-node metastasis,and chemotherapy regimen were all factors significantly affecting the survival（all P〈0.05）.In Cox multiple factor survival analysis stage,grade,residual disease after surgery,and lymph-node metastasis were available independent factors of PFTC（all P〈0.05）.Conclusion：The prognosis of PFTC was poor.Aggressive cytoreductive surgery followed by paclitaxel or platinum based chemotherapy offered the possibility of long-term control of PFTC.