胎盘生长因子对女性冠心病的诊断价值

Diagnostic Value of Placental Growth Factor in Female Coronary Artery Disease Patients

目的:比较女性胸痛患者和女性健康志愿者血浆中胎盘生长因子(placental growth factor,PlGF)水平,探讨胎盘生长因子在女性冠心病中的诊断价值。方法:对14例以胸痛为主要表现的女性患者行冠状动脉造影检查,同时抽静脉血测定血浆PlGF水平,另取11例女性健康志愿者静脉血测定血浆PlGF水平,进行组间比较。结果:根据冠状动脉造影结果,胸痛患者可分为冠心病组与非冠心病组。冠心病组血浆PlGF水平为12·71±0·58ng/L,明显高于非冠心病组(3·83±1·19ng/L)与对照组(3·76±0·61ng/L)(P<0·05),而非冠心病组与对照组间未见统计学差异。结论:检测血浆PlGF水平可能有助于女性冠心病的诊断,尤其在女性不明原因胸痛的鉴别诊断中具有一定意义。

Objective：To investigate the diagnostic value of plasma placental growth factor （PlGF） in female patients with coronary artery disease.Methods：The study population consisted of 14 female patients present with acute chest pain and 11 normal controls.Plasma PlGF was determined by an enzyme linked immunosorbent assay （ELISA）.All patients underwent coronary angiography.Results： According to the angiography,patients could be divided into CAD group and Non-CAD group.Plasma PlGF level in CAD group was significantly higher than that in Non-CAD group and control group （12.71±0.58ng/L vs 3.83±1.19ng/L vs 3.76±0.61ng/L,P〈0.05）,whereas no difference between the non-CAD group and control group.Conclusion：PlGF level has potentially diagnostic value in female patients with acute chest pain.The measurement of plasma PlGF might be helpful for early diagnosis of coronary artery disease.