糖尿病患者血糖、果糖胺、糖化血红蛋白、病程与尿微量白蛋白的相关性研究

Correlatory analysis of Blood Glucose,Fructosamine,Glycosylated Hemoglobin,Disease course and Urine Microalbumin in Diabetes Mellitus

目的:探讨糖尿病患者血糖、果糖胺、糖化血红蛋白、病程与尿微量白蛋白(mAlb)的相互关系。方法:检测119例门诊、住院内分泌专科不同病程非胰岛素依赖型糖尿病患者血糖、果糖胺、糖化血红蛋白、尿mAlb,同时做38例健康体检人员作对照。结果:糖尿病患者尿中的mAlb明显高于健康对照组,两组比较有显著性差异(P<0·01);糖尿病患者病程5-10年组与病程<5年组比较尿mAlb无显著性差异(P>0·10);糖尿病患者病程>10年组与病程<5年组比较尿mAlb有显著性差异(P<0·01);尿mALB与血糖、果糖胺、糖化血红蛋白分别呈正相关(r分别是0·3126、0·3258、0·4635),但与糖化血红蛋白相关性最为密切。结论:尿mAlb与糖尿病患者血糖、果糖胺、糖化血红蛋白、病程有着密切的关系,但与糖化血红蛋白相关性最为密切,糖尿病患者不能只重视血糖,还应重视对尿微量白蛋白、糖化血红蛋白的监测,对早期发现、诊断和治疗肾损害具有重要意义。

Objective：To stady the interrelationship of Blood Glucose,Fructosamine,Glycosylated Hemoglobin,Disease course and Urine Microalbumin in Diabetes Mellitus.Methods：Blood Glucose,Fructosamine,Glycosylated Hemoglobin and Urine Microalbumin were determined in 119 outpatients and Hospitalized Patients With different stages of non-insulin-dependent diabetes mellitus, and compared with 38 healthy peoples.Results：Urine Microalbumin in Diabetes Mellitus hgher than those in healthy peoples（P〈0.01）,there were no significant differences in Disease course of 5-10 years and 〈5 years（P〉0.10）,but there were significant difference between Disease course of 〉10 years and 〈5 years（P〈0.01）.Blood Glucose,Fructosamine and Glycosylated Hemoglobin are positively correlated with Urine Microalbumin （r=0.3126,0.3258,0.4635）,and there is a close correlation between Glycosylated Hemoglobin and Urine Microalbumin.Conclusion：Blood Glucose,Fructosamine and Glycosylated Hemoglobin are positively correlated with Urine Microalbumin,and there is a close correlation between Glycosylated Hemoglobin and Urine Microalbumin.Diabetes mellitus patients should be attached to Blood Glucose,and Urine Microalbumin,Glycosylated Hemoglobin as well.These test items were examined maybe very important in early discovery,diagnosis and treatment of the diseases of kidney injury.