高血压合并阻塞性睡眠呼吸暂停综合征与血清5-羟色胺水平的关系

The Correlation of Plasma 5-hytroxytryptamine and Hypertension Associated with Obstructive Sleep Apnea Syndrome

目的:探讨高血压合并阻塞性睡眠呼吸暂停综合征(OSAS)患者血浆5-羟色胺(5-HT)水平的变化。方法:应用放射免疫法测定45例高血压合并阻塞性睡眠呼吸暂停综合征患者血清5-HT浓度。结果:高血压合并阻塞性睡眠呼吸暂停综合症患者与单纯高血压不合并OSAS的患者相比,血压控制较差,而血浆5-HT水平明显增高(P<0.05),轻、中、重度阻塞性睡眠呼吸暂停综合征患者血浆5-HT水平之间相比较有差异(P<0.05)。结论:5-HT水平可能与血压控制和阻塞性睡眠呼吸暂停综合征的发病有关。

Objective：To study the changes of plasma 5-hytroxytryptamine（5-HT）in patients with hypertensions associated with obstructive sleep apnea syndrome（OSAS）.Methods：5-HT concentrations in the plasma from 45 cases of hypertension and OSAS were determined by radioimmunoassay.Results：Blood pressures were higher,and 5-HT concentrations increased significantly in the mild,moderate and severe OSAS and hypertension patients than that of patients with hypertension alone（P〈0.05）.There were significant differences between mile,moderate,and severe OSAS groups（P〈0.05）.Conclusion：5-HT may involve in the course of OSAS and the control of hypertension.