原发性胆汁性肝硬化17例临床分析
Clinical Review of 17 Primary Biliary Cirrhosis
摘要
目的:分析原发性胆汁性肝硬化(PBC)患者的临床特征,以提高对该病诊治的认识。方法:分析17例PBC患者的一般资料、临床表现、生化指标、免疫学指标及病理学改变。结果:PBC主要累及中年女性,易合并干燥综合征(SS)。胆管酶升高及抗线粒体M2抗体阳性有助于本病诊断。治疗首选熊去氧胆酸,糖皮质激素、免疫抑制剂适用于合并SS者。结论:早期诊断、早期治疗PBC是防止发展为终末期肝硬化的关键。
出处
《华西医学》
CAS
2008年第1期126-127,共2页
West China Medical Journal
参考文献5
-
1Bach N,Odin JA.Primary biliary cirrhosis:a Mount Sinai Perspective[J].Mt Sinai J Med,2003,70:242-250.
-
2Talwalkar JA,Lindor KD.Primary biliary cirrhosis[J].Lancet,2003,262:53-61.
-
3Neuberger J.Primary biliary cirrhosis[J].Lancet,1997,350:875-879.
-
4O′Donohue J,Williams R.Primary biliary cirrhosis[J].Q J Med,1996,89:5-13.
-
5张烜,唐福林.原发性胆汁性肝硬化临床诊治的认识[J].中华风湿病学杂志,2004,8(6):324-326. 被引量:5
二级参考文献16
-
1Bandin O, Courvalin JC, Poupon R, et al. Specificity and sensitivity of gp210 autoantibodies detected using an enzyme-linked immunosorbent assay and a synthetic polypeptide in the diagnosis of primary biliary cirrhosis. Hepatology, 1996, 23: 1020-1024.
-
2Bach N, Odin JA. Primary biliary cirrhosis: a Mount Sinai perspective. Mt Sinai J Med, 2003, 70: 242-250.
-
3Kamihira T, Shimoda S, Harada K, et al. Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis. Gastroenterology, 2003, 125: 1379-1387.
-
4Mitchison HC, Palmer JM, Bassendine MF, et al. A controlled trial of prednisolone treatment in primary biliary cirrhosis: threeyear results. J Hepatol, 1992, 15: 336-344.
-
5Leuschner M, Guldutuna S, You T, et al. Ursodeoxycholic acid and prednisolone versus ursodeoxycholic acid and placebo in the treatment of early stages of primary biliary cirrhosis. J Hepatol,1996, 25: 49-57.
-
6Chan CW, Papatheodoridis GV, Goulis J, et al. Ursodeoxycholic acid and histological progression in primary biliary cirrhosis. J Hepatol, 2003, 39: 1094-1095.
-
7Talwalkar JA, Lindor KD. Primary biliary cirrhosis. Lancet, 2003,262: 53-61.
-
8Muratori P, Muratori L, Ferrari R, et al. Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis. Am J Gastroenterol, 2003, 98: 431-437.
-
9Ikuno N, Mackay IR, Jois J, et al. Antimitochondrial autoantibodies in saliva and sera from patients with primary biliary cirrhosis.J Gastroenterol Hepatol, 2001, t6: 1390-1394.
-
10Metcalf JV, Mitchison HC, Palmer JM, et al. Natural history of early primary biliary cirrhosis. Lancet, 1996, 348: 1399-1402.
共引文献4
-
1张福奎,张俊勇,贾继东,王宝恩.原发性胆汁性肝硬化52例误诊原因分析[J].临床误诊误治,2005,18(2):90-91. 被引量:3
-
2戴芸,梁颖慧,谢鹏雁,陈宝雯,刘新光.42例原发性胆汁性肝硬化临床分析[J].北京大学学报(医学版),2005,37(4):410-414. 被引量:13
-
3鄢志红,张川波,谢其冰.原发性胆汁性肝硬化25例分析[J].现代临床医学,2006,32(4):261-263.
-
4吴杭源.原发性胆汁性肝硬化18例临床分析[J].淮海医药,2008,26(5):414-415.
-
1罗德梅,赵春梅,张琼,罗莉.新疆维吾尔族原发性胆汁性肝硬化患者的生化和免疫学特征[J].中国免疫学杂志,2010,26(9):842-844. 被引量:1
-
2姚勇.中西药结合治疗原发性胆汁性肝硬化临床观察[J].中国基层医药,2010,17(8):1070-1072. 被引量:2
-
3蒋健,高月求,等.慢性活动性肝炎-原发性胆汁性肝硬化混合型一例[J].中华国际医学杂志,2001,1(1):37-37.
-
4陈叶青,周国华,刘树旗,王为.原发性胆汁性肝硬化误诊5例分析[J].中国误诊学杂志,2011,11(24):5903-5904. 被引量:3
-
5程玉萍.原发性胆汁性肝硬化与抗线粒体抗体相关性的研究进展[J].临床误诊误治,2008,21(7):81-82.
-
6王侠,冯明.原发性胆汁性肝硬化42例分析[J].中国误诊学杂志,2009,9(15):3708-3708.
-
7刘红虹,福军亮,付宝云,张政,徐若男,罗生强,施明,李永纲,王福生.原发性胆汁性肝硬化的发病机制及影响预后的危险因素研究进展[J].临床肝胆病杂志,2012,28(2):153-155. 被引量:9
-
8杨金龙.原发性胆汁性肝硬化与抗线粒体抗体间的关系[J].国外医学(消化系疾病分册),1999,19(4):223-224.
-
9刘文.原发性胆汁性肝硬化7例临床报告并文献复习[J].临床消化病杂志,2004,16(3):125-126.
-
10张秀铮,刘汉超.丙型肝炎若干免疫学指标的检测[J].临床检验杂志,1992,10(2):99-100. 被引量:8