睾酮影响兔阴茎勃起功能的实验观察

An experimental study on effects of testosterone on erectile function of the rabbits

目的评价睾酮对兔阴茎勃起功能的影响。方法 45只雄性新西兰白兔,等分成对照组(C组)、去势组(Ox组)、睾酮替代治疗组(OxT组)。依据替代治疗的睾酮剂量不同,OxT组再等分为OxTa组、OxTb组、OxTc组3个亚组。在第2周、4周、8周测定血清睾酮浓度(STL)、海绵体内压(ICP)和颈动脉血压(SAP)。结果第2周、4周、8周,Ox组STL分别降至C组的17%、14%和13%;ICP(Ox组/C组)分别为(59.3±3.1)/(92.5±4.6)mmHg、(55.7±3.4)/(91.7±3.8)mmHg和(53.6±2.8)/(92.3±4.4)mmHg。睾酮替代治疗8周后,OxTa组、OxTb组和OxTc组ICP分别为(57.6±3.4)mmHg、(73.9±2.9)mmHg和(90.2±4.8)mmHg。Ox组、OxTa组和OxTb与C组之间的ICP峰值差异有统计学意义(P<0.01),而OxTc组与C组之间差异无统计学意义(P>0.05)。各组ICP基线值及SAP值差异无统计学意义(P>0.05)。结论STL降低,可以引起ICP峰值下降,补充睾酮,ICP可以恢复正常。因此,我们推测睾酮是影响阴茎勃起功能的重要因素。

Objective To evaluate the effects of testosterone on erectile function of the rabbits. Methods Total of 45 male New Zealand White rabbits were equally divided into Ox group （castration group）, OxT group （replace treatment with T）and C group（control group）. Based on the dosage of testosterone used in castrated rabbits, OxT group was further divided into 3 subgroups（OxTa group, OxTb group, OxTc group）. Four weeks after castration, the 3 sub- groups were injected with 0mg/kg, 15mg/kg and 30mg/kg of testosterone, respectively. And levels of serum T （STL）, ICP and ASP values（basal and peak values） were detected at 2, 4, 8 weeks after castration. Results At 2,4 and 8 weeks after castration, the level of serum STL decreased to 17%,14% and 13% of that in group C respectively; And the peak of ICP（Ox group/C group）were （59.3±3.1）/（92.5±4.6）mmHg, （55.7±3.4）/（91.7±3.8）mmHg and （53.6±2.8）/（92.3±4.4） mmHg, respectively. After 8 weeks of T replacement therapy, ICP （OxTa group,OxTb group and OxTc group） were （57.6±3.4）mmHg, （73.9±2.9）mmHg and （90.2±4.8） mmHg,respcctively.Therc were no significant differences between C group and OxTc group （P〉0.05）. And the differences in ICP were significance between Ox group,OxTb group,OxTc group and C group （P〈0.01）. No significant difference was found in SAPs among groups. Conclusion The level of STLs could result in changeand normal peak ICPvalues could be restored by replacement therapy with testosterone It suggested that that testosterone mightplay an important role in erectile function.