急性冠状动脉综合征患者血清sICAM-1、sVCAM-1表达与可溶性P-选择素关系的研究被引量：1

Study of serum intercellular adhesion molecule-1,vascular adhesion Molecule-1,and P-selectin in patients with coronary heart disease

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摘要目的:观察急性冠脉综合征(ACS)患者血清中可溶性细胞间黏附分子-1(sICAM-1)、血管细胞黏附分子-1(sVCAM-1)及P选择素(sP-selectin)水平的变化。方法:选择稳定型心绞痛患者(SAP组)30例、不稳定型心绞痛患者(UA组)30例、急性心肌梗死患者(AMI组)25例,采用ELISA法检测其外周血血清可溶性P选择素、sICAM-1和sVCAM-1水平。以健康体检者30例作为对照。结果:ACS组血清sICAM-1、sVCAM- 1、sP-selectin水平显著高于SAP组和对照组(均P<0.01),SAP组与对照组无显著性差异(P>0.05)。ACS患者血清sICAM-1、sVCAM-1与sP-selectin呈显著正相关(r=0.519,0.517,均P<0.05)。结论:ACS患者血清sICAM-1、sVCAM-1和sP-selectin水平均明显升高,它们共同作用促进ACS的发生和发展。 Objective ： To explore the changes of serum intercellular adhesion molecule-1 （sICAM- 1 ） ,vascular adhesion molecule-1 （ sVCAM-1 ）, and P-selectin level in patients with coronary heart disease. Methods ： A total of 85 patients with coronary heart disease, including 30 cases of SAP, 30cases of UA,and 25 cases of AMI, were subjected to detect the serum levels of sICAM-1, sV- CAM-1, and P-selectin using ELISA method. Fifty normal individuals was used as control. Resuits： Compared with those of control, the serum levels of the four indexes mentioned above of AMI, UA, and SAP groups （ P 〈 0.01 ） were higher. Conclusion ： The four indexes mentioned above may involve in the pathogenesis and process of coronary heart disease, and might be an available index that reflexes the sevenity of coronary heart disease.

作者徐利霞

机构地区郑州市第二人民医院心内科

出处《河南医学研究》 CAS 2008年第3期193-195,共3页 Henan Medical Research

关键词可溶性细胞间黏附分子-1 血管细胞黏附分子-1 可溶性P-选择素急性冠状动脉综合征 coronary heart disease intercellular adhesion molecule-1 vascular adhesion molecule-1 P-selectin

分类号 R541.4 [医药卫生—心血管疾病]

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参考文献5

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