期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

黏膜免疫系统相关免疫细胞、免疫分子及淋巴细胞归巢研究进展 被引量：4

The study of mucosal immunization systerm
下载PDF
导出
摘要 黏膜是病原菌重要的入侵门户，通过黏膜免疫可以从感染的源头上阻止病原菌的侵入。早在20世纪80年代，随着生物工程技术、分子生物学、药物投递系统及黏膜免疫调节理论的发展，以及对注射疫苗的不易接受性，人们对黏膜免疫的兴趣陡然增加。本世纪初WHO提出将采取更有效的免疫方法来减少注射免疫所带来的器材污染、费用高昂、容易耐受等问题。
作者 白雪飞
机构地区 河南科技大学医学技术与工程学院
出处 《河南医学研究》 CAS 2008年第3期270-273,共4页 Henan Medical Research
关键词 黏膜免疫系统 淋巴细胞归巢 免疫细胞 免疫分子 生物工程技术 药物投递系统 分子生物学 免疫调节
分类号 R446.12 [医药卫生—诊断学] R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献26

  • 1Giudice EL, Campbell JD. Needle-free vaccine delivery [ J]. Adv Drug Deliv Rev, 2006, 58( 1 ) : 68-89.
  • 2Czyzewska A, Majkowska-Skrobek G. Discovering of mucosal immunity[ J]. Pol Merkuriusz Lek, 2005, 19 (112) : 580-583.
  • 3Vajdy M, O'Hagan DT. Microparticles for intranasal immunization [J]. Adv Drug Deliv Rev, 2001, 51(1-3): 127-141.
  • 4Kiyono H, Fukuyama S. NALT-versus Peyer's-patch-mediated mucosal immunity[J]. Nat Rev Immunol, 2004, 4(9) :699-710.
  • 5Holmgren J, Czerkinsky C, Eriksson K, Mharandi A. Mucosal immunization and adjuvants : a brief overview of recent advances and challenges[J]. Vaccine, 2003, 21(2):89-95.
  • 6Gebert A, Tsang LL, Ho LS, et al. Antigen transport into Peyer's patches: increased uptake by constant numbers Of M cells[ J]. Am J Pathol, 2004, 164(1 ): 65-72.
  • 7Jang MH, Kweon MN, Iwatani K, et al. Intestinal villous M cells: an antigen entry site in the mucosal epithelium [ J]. Proc Nat Acad Sci USA, 2004, 101(16) :6110-6115.
  • 8Man AL, Prieto-Garcia ME, Nicoletti C. Improving M cell mediated transport across mucosal barriers: do certain bacteria hold the keys? [J]. Immunology, 2004, 113(1):15-22.
  • 9Mantis N J, MC Cheung, KR Chintalacharuvu, et al. Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor[ J]. Immunol, 2002, 169 (4):1844-1851.
  • 10Neutra MR, Mantis N J, Kraehenbuhl JP. Collaboration of epithelial cells with organized mucosal lymphoid tissues [ J ]. Nat Immunol, 2001, 2 ( 11 ) : 1004-1009.

二级参考文献22

  • 1[1]Blumberg，RS，Lencer WI，Zhu XP，et al．Antigen presentation by intestinal epithelial cells．Immunol Letters，1999；69:7
  • 2[2]Campbell N，Yio XY，So LP，et al．The intestinal epithelial cell:Processing and presentation of antigen to the mucosal immune system．Immunol Rew，1999；172:315
  • 3[3]Beagley KW，Husband AJ．Intraepithelial lymphocytes，origins，origins，distribution and function．Crit Rew Immunol，1998；18:237
  • 4[4]Planchon S，Fiocchi c，Takafuji V，et al．Transforming growth factor-beta l preserves epithelial barrier function identification of receptors，biochemical intermediates，and cytokine antagonists．J Cell Physiol，1999；181:55
  • 5[5]Framson PE，Cho DH，Lee LY，et al．Polarized expression and function of the costimulatory molecule CD58 on human intestinal epithelial cells．Gastroenterology，1999；116:1054
  • 6[6]Weiner HL，Van Rees EP．Mucosal tolerance．Immunol Letters，1999；69:3
  • 7[7]Gebcrt A，Fassbender S，Werner K，et al．The development of M cells in peyer’s patches is restricted to specialized dome-associated crypts．Am J Paty，1999；154:1573
  • 8[8]Debard N，Sierro F，Kraehenbuhl JP．Development of peyer’s patches，follicle-associated epithelium and M cell:Lessons from immunodeficient and knockout mice．Semi Immunol，1999；11:183
  • 9[9]Neutra MR．Current concepts in mucosal immunity，V Role of M cells in transepithelial transport of antigens and pathogens to the mucosal immune system．Am J Physiol，1998；274:G785
  • 10[10]Neutra MR，Mantis NJ，Frey A，et al．The composition and function of M cell apical membranes:Implications for microbial pathogenesis．Semi Immunol，1999；11:171

共引文献48

同被引文献40

  • 1刘铁民,许豪文.过度训练大鼠肠粘膜超微结构、MDA和IgA变化的研究[J].广州体育学院学报,2001,21(1):54-58. 被引量：7
  • 2范骏,谢勇（审校者）.肠道黏膜免疫[J].国际免疫学杂志,2006,29(2):111-115. 被引量：33
  • 3Wittig B M, zeitzm. The gut as an organ an organ of immunology[J]. Int J Color-ectal Dis, 2003,18 : 181-187.
  • 4Charles A Janeway.免疫生物学[M].5版.北京:科学出版社,2008.
  • 5Xu Yx, Ayala A, Monfils B, et al. Mechanism of intestinal mucosal immune dysfunction folloeing tranma-hrmorrhage: increase opoptosis associated with elevated Fas expression in peyer' s patches[J]. J SURG RES, 1997, 70: 55-60.
  • 6Tiollier E. Intense training: mucosal immunity and incidence of respiratory infections[J]. J Eur J Appl Physiol, 2005(93): 421-428.
  • 7Boudreau J, Quadrilatero J, Hoffman-Goetz L, et al. Voluntary training in mice and submandibular lympho- cyte response to acute exercise[J]. Med Sci Sports Ex- erc, 2005, 37(12): 2038-2045.
  • 8Korsmeyer S J. Bcl-2 Investigation of the subeellu- lar distribution of the bcl-2 ooncoprotein :residence in the cuclear envelope, endoPlasmicreticulum and outer mitochondrial membranes[J]. Cancer Res, 1993, 53(19): 4701-4714.
  • 9邓海燕,贾立群,潘琳,于莉莉,李学,郭艳茹.生姜泻心汤对伊立替康化疗后大鼠肠黏膜免疫屏障的影响[J].中国免疫学杂志,2007,23(7):620-622. 被引量：22
  • 10BRANDTZAEG P. Mucosal immunity: integration between mother and the breast-fed infant[J]. Vaccine, 2003, 21 (24) : 3382 - 3388.

引证文献4

二级引证文献34

河南医学研究
2008年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部