卡泊芬净在器官移植术后侵袭性真菌感染病人中的应用

Evaluation of efficacy and safety of caspofungin for invasive fungal infection in recipients after organ transplantion

目的对卡泊芬净治疗器官移植术后侵袭性真菌感染的疗效进行评价。方法采用病例对照研究方法,选择我院器官移植术后出现侵袭性真菌感染病人100例,分为3组。卡泊芬净组36例,氟康唑组36例,两性霉素B组28例,分别予卡泊芬净、氟康唑和两性霉素B治疗,观察抗真菌治疗疗效。结果卡泊芬净组、氟康唑组和两性霉素B组抗真菌治疗的有效率分别为76%、81%和67%,3组疗效无显著差异(P>0.05)。卡泊芬净组与氟康唑组、两性霉素B组用药过程中的不良反应发生率分别为6%、6%和14%。结论卡泊芬净对于器官移植术后病人侵袭性真菌感染有明显的治疗作用,疗效与两性霉素B和氟康唑相当。

AIM To get a systematic evaluation of therapeutic effects and incidence of adverse reactions of caspofungin for invasive fungal infection in recipients after organ trasplantion. METHODS One hundred patients after organ transplantations with invasive fungi infection were divided into three groups. The patients in caspofungin group （36 patients）, fluconazol group （36 patients） and amphotericin B group （28 patients） were administrated with caspofungin, fluconazol and amphotericin B, respectively. The clinical effect and adverse reactions were observed. RESULTS The effective rates of caspofungin group, fluconazol group and amphotericin B group were 76 %, 81% and 67 %, respectively （P 〉 0.05） . The incidence of adverse reactions in the three groups were 6 %, 6 %and 14 %, respectively. CONCLUSION Caspofungin has equivalent therapeutic effect comparing with fluconazol and amphotericin B.