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乙型肝炎病毒X蛋白在HBV复制中作用的研究进展

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作者 王月宾 唐红
机构地区 四川大学华西医院感染性疾病中心生物治疗国家重点实验室感染性疾病研究室
出处 《华西医学》 CAS 2008年第4期917-918,共2页 West China Medical Journal
基金 国家杰出青年基金(No.30325036) 国家自然科学基金(No.30570064)
关键词 乙型肝炎病毒X蛋白 HBV复制 乙型肝炎病毒(HBV) 嗜肝DNA病毒 公共卫生问题 机体免疫反应 肝脏细胞 高发区
分类号 R512.62 [医药卫生—内科学]
  • 相关文献

参考文献27

  • 1Murakami S. Hepatitis B virus X protein: a muhifunctional viral regulator [ J]. J Gastroenterol, 2001, 36 (10): 651-660.
  • 2Becker SA, Lee TH, Butel JS, Slagle BL. Hepatitis B virus X protein interferes with cellular DNA repair [ J ]. J Viral, 1998, 72 (1): 266-272.
  • 3Gottlob K, Fulco M, Levrero M, et al. The hepatitis B virus HBx protein inhibits caspase 3 activity [J]. J Biol Chem, 1998, 273 (50): 33347-33353.
  • 4刘晓红,林静,曹晓哲,郑建明,陈颖,朱明华.乙型肝炎病毒X蛋白羧基端氨基酸缺失对肝癌细胞生物学行为的影响[J].中华医学杂志,2005,85(12):825-830. 被引量：13
  • 5Nijhara R, Jana SS, Goswami SK, et al. An internal segment (residues 58- 119) of the hepatitis B vires X protein is sufficient to activate MAP kinase pathways in mouse liver [J]. FEBS Lett, 2001, 504 (1-2): 59 -64.
  • 6Choi BH, Park GT, P, ho HM. Interaction of hepatitis B viral X protein and CCAAT/ enhancer- binding protein alpha synergistically aetivates the hepatitis B viral enhancer Ⅱ/pregenonic promoter [J]. J Biol Chem, 1999, 274 (5): 2858- 2865.
  • 7Le TF, Zhang S, Hayashi N, et al. Mutational analysis of human RNA polymerase Ⅱ subunit 5 ( RPB5 ) : the residues critical for interactions with TF Ⅱ F subunit RAP30 and hepatitis B virus X protein [J]. J Biochem, 2005, 138 (3): 215-224.
  • 8Tang H, Delgermaa L, Huang F, et al. The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication [J]. J Virol, 2005, 79 (9): 5548-5556.
  • 9Henkler F, Hoare J, Waseem N, et al. Intraceltular localization of the hepatitis B virus HBx protein [J]. J Gen Virol, 2001, 82 (Pt4): 871-882.
  • 10Lee YI, Hwang JM, Im JH, et al. Human hepatitis B virus- X protein alters mito-chondrial function and physiology in human liver cells [J]. J Biol Chem, 2004, 279 (15): 15460- 15471.

二级参考文献13

  • 1林静,朱明华,曲建慧,李芳梅,倪灿荣.乙型肝炎病毒X基因经p53依赖性与非依赖性途径对p21^(WAF1)表达的影响[J].癌症,2004,23(7):749-755. 被引量：9
  • 2Birrer RB, Birrer D, Klavins JV. Hepatocellular carcinoma and hepatitis virus. Ann Clin Lab Sci, 2003, 33:39-54.
  • 3Tu H, Bonura C, Giannini C,et al. Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Res, 2001, 61: 7803-7810.
  • 4Sirma H, Giannini C, Poussin K, et al. Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene,1999,18:4848-4859.
  • 5Iavarone M, Trabut JB, Delpuech O, et al. Characterisation of hepatitis B virus X protein mutants in tumour and non-tumour liver cells using laser capture microdissection. J Hepatol, 2003, 39: 253-261.
  • 6Murakami S, Cheong JH, Kaneko S. Human hepatitis B virus X gene encodes a regulatory domain that represses transactivation of X protein. J Biol Chem,1994,269:15118-15123.
  • 7Elmore LW, Hancock AR, Chang SF, et al. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc Natl Acad Sci U S A, 1997, 94:14707-14712.
  • 8Feitelson MA, Clayton MM. X antigen/antibody markers in hepadnavirus infections. Antibodies to the X gene product(s).Gastroenterology, 1990, 99: 500-507.
  • 9Shih WL, Kuo ML, Chuang SE, et al. Hepatitis B virus X protein inhibits transforming growth factor-beta -induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway. J Biol Chem, 2000, 275: 25858-25864.
  • 10Schuster R, Gerlich WH, Schaefer S. Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts. Oncogene, 2000, 19:1173-1180.

共引文献14

华西医学
2008年 第4期

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