3-甲胺基哌啶二醋酸盐的合成工艺改进

An improved method for synthesis of 3-methylaminopiperidine diacetate

目的:合成3-甲胺基哌啶二醋酸盐。方法:以3-氨基吡啶为起始原料,经3步反应制得3-甲胺基哌啶二醋酸盐。结果:目标化合物经1H-NMR和MS确证,总收率为41.4%。结论:本方法优化了反应条件和投料比,缩短了反应时间,提高了收率,适合工业化生产。

Objective ： To synthesize 3-methylaminopiperidine diacetate. Methods ： 3-Methylaminopiperidine diacetate was synthesized via 3-step reactions with 3-aminopyridine as the starting material. Results： The total yield of 3-methylaminopiperidine diacetate was 41.4%. Conclusion： The improved method optimizes the synthetic process and is worthy to a further pilot manufacture.