新型喹诺酮类抗菌药加雷沙星

Garenoxacin,a novel quinolone antimicrobial agent

加雷沙星为一新型广谱喹诺酮类抗菌药,它不仅保持了喹诺酮类抗菌药对G-菌的抗菌活性,对G+菌的抗菌活性也明显增强,临床主要用于治疗呼吸系统感染,泌尿系统感染和皮肤,软组织感染等疾病。其结构中喹诺酮母核6位去除氟不但可以改善活性,而且可降低药物不良反应。现对其药动学、药理作用、临床应用及安全性等作一综述。

Garenoxacin is a novel, broad-spectrum quiolone. It remains the antimicrobial activity against Gram-negative bacteria, and remarkably enhances the activity against Gram-positive bacteria. It is mainly used for various infections, such as the infection of respiratory system, urinary system, cutis and parenchyma systems. As compared to other quiolones, the des-F6-quinolone not only can improve anti-bacterial activity, but also reduce adverse drug reactions （ADRs）. Currently, it has come into the market in Japan. In this article, we summarized its pharmacokinetics, pharmacological effect, clinical use and safety.