有氧运动对大鼠动脉粥样硬化发生发展中血浆CO和cGMP的影响

The Effect of Aerobic Exercise on CO and cGMP in Rat's Plasma during the Progression of Atherosclerosis

目的:探讨有氧运动预防动脉粥样硬化发生发展过程中,血浆一氧化碳(CO)的变化及CO发挥作用的可能机制。方法:高脂膳食建立大鼠动脉粥样硬化模型过程中,分别给大鼠以每天60 min和120 min的游泳训练,8周后检测血浆CO和环磷酸鸟苷(cGMP)含量。结果:在大鼠动脉粥样硬化发生发展中,动脉粥样硬化组血浆CO和cGMP含量较对照组明显升高(P<0.05),60 min和120 min的游泳训练组血浆CO和cGMP含量较动脉粥样硬化组明显降低(P<0.05),游泳训练两组之间组血浆CO和cGMP含量无显著性差异(P>0.05)。血浆CO的变化与cGMP的变化成正相关(相关系数r=0.78)。结论:动脉粥样硬化发生发展过程中血浆CO和cGMP含量升高,有氧运动可使升高的血浆CO和cGMP含量降低,CO-cGMP途径可能是CO发挥效应的机制之一。

Objective： To investigate the effects of aerobic exercise on CO and cGMP in plasma in the progression of atherosclerosis（AS）,and to find the possible mechanisms of preventing and ameliorating AS by aerobic exercise.Methods： The model of AS of rats induces by atherogenic diet,and the rats are given different aerobic exercise（60 minutes per day and 120 minutes per day）.After 8 weeks, CO and cGMP content in plasma is measured.Results： CO and cGMP content in plasma in the AS group is increased significantly（P〈0.05）.Compared with AS group,CO and cGMP content in plasma is decreased significantly（P〈0.05） in both 60 minutes group and 120 minutes group.CO and cGMP content in plasma has no difference between 60 minutes group and 120 minutes group（P〉0.05）.The changes of CO are correlated with the changes of cGMP.Conclusions： CO and cGMP content in plasma increase during the progression of AS,aerobic exercise may reduce CO and cGMP content,CO-cGMP might be one of the mechanisms of preventing and ameliorating AS by aerobic exercise.