摘要
血脑屏障(blood-brain barrier,BBB)的存在使98%的药物无法进入脑组织,是制约神经系统药物发展的重要因素。纳米粒载药系统能够透过BBB,并提高脑内药物浓度,是实现脑内靶向给药的良好载体,但其透过BBB的机制至今尚未完全明白。自从2001年Kreuter提出关于纳米粒(nanoparticles,NP)透过BBB的6点可能机制后,针对此机制并进而提高载药NP入脑效率的探讨已成为热点之一,文中就目前NP穿透BBB机制研究进展做一综述。
The existence of blood-brain barrier（BBB） makes it impossible for 98% medicines to enter the brain.This is an important restrictive factor for the development of central nervous drugs.By nanoparticle delivery system,drugs can cross the BBB and increase the drug concentration in brain.This system is a better carrier for drugs to target brain,but the mechanism how it permeate the BBB is not completely understood.Since Kreuter proposed six plausible mechanisms for nanoparticles（NP） across the BBB in 2001,it has become a hot spot to investigate these mechanisms in order to enhance the drug-loaded NP permeability across the BBB.This article mainly reviewed the present research progress in mechanisms of NP across the BBB.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2008年第21期1831-1833,共3页
Chinese Journal of New Drugs
基金
福建省自然科学基金(2006J0188)
关键词
纳米粒
血脑屏障
靶向药物
药物载体
中枢神经系统
nanoparticles
blood-brain barrier
drug targeting
drug carriers
central nervous system
