氨酚羟考酮片治疗142例不同类型中重度癌性疼痛的疗效和不良反应

Efficacy and safety of oxycodone-acetaminophen tablet in 142 patients with different types of moderate and advanced cancer pain

目的:观察氨酚羟考酮片在不同类型的中重度癌性疼痛中的治疗作用及不良反应。方法:采用多中心随机对照试验方法,将总共283例躯体痛、内脏痛、神经病理性疼痛的患者随机分为试验组(氨酚羟考酮片)和对照组(等效剂量吗啡片),观察其镇痛效果及不良反应。结果:对于躯体痛和内脏痛,试验组治疗前后疼痛强度差及镇痛有效率明显高于对照组;而对于神经病理性疼痛,两组之间无显著性差异。并且用药期间显示试验组胃肠道不良反应较对照组低。结论:氨酚羟考酮可作为治疗中重度肿瘤伤害性疼痛的首选药物之一。

Objective： To observe the analgesic effect and safety of oxycodone-acetaminophen tablet（Tylox） on different types of moderate and advanced cancer pain.Methods： We conducted a multi-center,randomized and controlled trial.A total of 283 patients with cancer pain,including somatic,visceral,and neuropathic pain,were randomly divided into two groups： the test（Tylox） and control（equivalent dose of morphine） groups.The analgesic effect and adverse reactions were observed.Results： The difference in pain intensity and the analgesic efficiency were significantly higher in the test group than in the control group for somatic and visceral pain,but there were no significant difference between the two groups for neuropathic pain.The incidence of gastrointestinal side effects was lower of test group during the test.Conclusion： Tylox can be used as one of the first choices in the treatment of cancer nociceptive pain.