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白介素-1及其基因多态性与骨关节炎 被引量：3

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摘要 流行病学研究表明骨关节炎(OA)是遗传与环境因素共同作用、多因子参与的一种复杂性疾病。众多研究提示细胞因子及其传导通路在OA的发生和发展中起到重要作用.其中白介素-1(IL-1)通过多种途径加速软骨的分解代谢。抑制其合成代谢.导致软骨的稳态平衡破坏及退行性变.从而促进OA的发生、发展。研究表明编码IL-1相关蛋白的IL-1基因簇的某些多态性位点与OA易感性相关.这些基因多态性位点有可能引起体内IL-1及其效应通路对关节软骨及周围组织的生物效应发生改变.最终促进IL-1在OA发病中的作用。IL-1基因多态性与OA易感性研究从遗传学角度揭示了IL-1与OA的关系。
作者 倪海键 史冬泉 蒋青
机构地区 南京大学医学院附属鼓楼医院骨科
出处 《国际骨科学杂志》 2008年第6期392-394,共3页 International Journal of Orthopaedics
基金 国家自然科学基金(30571874)
关键词 白介素-1 发病机制 基因 多态性 骨关节炎
分类号 R684.3 [医药卫生—骨科学]
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参考文献41

  • 1Peach CA, Carr A J, Loughlin J. Rccent advances in the genetic investigation of osteoarthritis. Trends Mol Med, 2005; 11 (4) : 186-191
  • 2Arden N, Nevitt MC. Osteoarthritis: epidemiology. Best Pract Res Clin Rheumatol, 2006; 20(1):3-25
  • 3Biota AB, van der Kraan PM, van den Berg WB. Cytokine targeting in osteoarthritis. Curr Drug Targets, 2007; 8(2):283-292
  • 4Malemud CJ, Islam N, Haqqi TM. Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies. Cells Tissues Organs, 2003; 174(1-2): 34-48.
  • 5Towne JE, Garka KE, Renshaw BR, et al. Interleukin (IL)-1F6, IL-1F8, and I:-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF kappaB and MAPKs. J Biol Chem, 2004; 279(14):13677-13688
  • 6Nicklin MJ, Weith A, Duff GW. A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1beta, and interleukin-1 receptor antagonist genes. Genomics, 1994; 19(2):382-384
  • 7Pelletier JP, McCollum R, Cloutier JM, et al. Synthesis of metalloproleases and interleukin 6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process. J Rheumatol Suppl, 1995; 43:109-114
  • 8Kronheim SR, Mumma A, Greenstreet T, et al. Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor. Arch Biochem Biophys, 1992; 296(2):698-703
  • 9Slack J, McMahan CJ, Waugh S, et al. Independent binding of interleukin-1 alpha and interleukin-1 beta to type Ⅰ and type Ⅱ interleukin-1 receptors. J Biol Chem, 1993; 268(4) :2513-2524
  • 10Kobayashi M, Squires GR, Mousa A, et al. Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum, 2005; 52(1):128-135

二级参考文献31

  • 1Spector TD,MacGregor AJ.Risk factors for osteoarthritis:genetics.Osteoarthritis Cartilage,2004; 12(Suppl A):S39-S44
  • 2D'Ambrosia RD.Epidemiology of osteoarthritis.Orthopedics,2005; 28(2 Suppl):S201-S205
  • 3Loughlin J.Genome studies and linkage in primary osteoarthritis.Rheum Dis Clin North Am,2002; 28(1):95-109
  • 4Mototani H,Mabuchi A,Saito S,et al.A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese.Hum Mol Genet,2005; 14(8):1009-1017
  • 5Berchtold MW,Egli R,Rhyner JA,et al.Localization of the human bona fide calmodulin genes CALM1,CALM2,and CALM3 to chromosomes 14q24-q31,2p21.1-p21.3,and 19q13.2-q13.3.Genomics,1993; 16(2):461-465
  • 6Li L,Wei DQ,Wang JF,et al.Computational studies of the binding mechanism of calmodulin with chrysin.Biochem Biophys Res Commun,2007; 358(4):1102-1107
  • 7Roberts SR,Knight MM,Lee DA,et al.Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs.J Appl Physiol,2001; 90(4):1385-1391
  • 8Valhmu WB,Stazzone EJ,Bachrach NM,et al.Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression.Arch Biochem Biophys,1998; 353(1):29-36
  • 9Valhmu WB,Raia FJ.Myo-Inositol 1,4,5-trisphosphate and Ca2+/calmodulindependent factors mediate transduction of compression-induced signals in bovine articular chondrocytes.Biochem J,2002; 361(Pt 3):689-696
  • 10Alsalameh S,Amin R,Gemba T,et al.Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage.Arthritis Rheum,2004; 50(5):1522-1532

共引文献3

同被引文献60

  • 1亓建洪,赵庆华,刘延菊,李亚鲁.白细胞介素-1β对人软骨细胞基质金属蛋白酶-13 mRNA表达的作用[J].中华风湿病学杂志,2005,9(3):138-141. 被引量：18
  • 2林木南,刘献祥.骨性关节炎中细胞因子的协同效应[J].福建中医学院学报,2006,16(2):69-70. 被引量：57
  • 3邢联平,张倩,姚振强.破骨细胞介导炎症性骨丢失的研究进展[J].中华创伤骨科杂志,2006,8(7):671-674. 被引量：8
  • 4康磊,郭雄,徐小洁,周玉玲.骨关节病的基因易感性研究进展[J].中国地方病学杂志,2006,25(6):731-733. 被引量：1
  • 5芮云峰,张晓玲,王友.骨关节炎治疗相关基因研究进展[J].国际骨科学杂志,2007,28(2):77-80. 被引量：5
  • 6Zwerina J,Polzerl K,Gasser J,et al. Dissecting the role of IL - 1 for synovitis,cartilage damage and bone erosion in routine TNF - induced polyarthritis[ J ]. Ann Rheum Dis, 2006,65 ( 2 ) : 143 - 147.
  • 7Dai SM,Shan ZZ,Nakamura H,et al. Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1 :possible involvement of eaveolin I - induced down - regulation of articular chondrocytes in the pathogenesis of osteoarthritis [ J ]. Arthritis and Rheumatism ,2006,54 (3) : 818 - 831.
  • 8Carames B, Lopez - Armada M j, Cillero - Pastor B, et al. Differential effects of tumor necrosis factor - otand intedeukin - 1βon cell death in human articular chondrocytes[ J]. Osteoarthritis and Cartilage,2008,16 (6) : 715 - 722.
  • 9Lopez Armada MJ,Carames B, Lires Dean M,et al. Cytokines, tumor necrosis factor - alpha and interleukin - lbeta,differentially regulate apoptosis in osteoarthritis cultured human chondrocytes [ J ]. Osteoarthritis and Cartilage,2006,14 ( 7 ) : 660 - 669.
  • 10Raymond L,Eck S,Hays E,et al. RelA is required for IL - 1beta stimulation of Matrix Metalloproteinase - 1 expression in chondrocytes [ J ]. Ostebarthritis and Cartilage,2007,15 ( 4 ) : 431 - 441.

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国际骨科学杂志
2008年 第6期

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