中国人群血清总胆红素与冠心病和脑梗死疾病关系的Meta分析

Meta-analysis on relationship between serum total bilirubin and coronary artery disease or cerebral infarction in Chinese population

目的:采用循证医学的研究方法分析血清总胆红素水平与冠心病和脑梗死(即脑梗塞、卒中)的关系及意义。方法:通过文献检索收集相关病例对照研究,按照一定的标准将研究方法相近的文献归类、整理、数据汇总,然后以软件RevMan 4.2.8进行Meta分析。结果:分析结果显示血清总胆红素水平与冠心病和脑梗死呈现密切的负相关,其加权均数差(the weighted mean difference,WMD)为-3.64,95%可信区间(confidence interval,CI)分别为-4.01和-3.27。结论:低血清总胆红素者冠心病和脑梗死的发病率增加,胆红素在预防动脉粥样硬化性心、脑血管疾病中可能发挥一定的作用。

Objective ：To evaluate the serum total bilirubin （TB） and its clinical value in chinese patients with coronary artery disease or cerebral infarction disease by evidence based medical analysis. Methods： All related case - control studies were collected from all publications and meta - analysis to combined with the results of these studies were performed with software of Revman 4. 2. 8. Results ： A close negative relationship was found between serum TB and coronary artery disease or cerebral infarction diseases, the weighted mean difference （WDM） was -3.64 and the 95% confidence interval （CI） were -4.01 and -3.27 respectively. Conclusion： The lower serum TB is associated with increased risk of coronary artery disease and cerebral infarction. The biliruhin may play an important role in the prevention of coronary artery disease and cerebral infarction.