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岩黄连生物碱自微乳的制备及体外评价 被引量:5

Preparation and in Vitro Evaluation of Self-Microemulsifying Drug Delivery System with Alkaloids from Corydalis saxicola Bunting
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摘要 目的以岩黄连生物碱自乳化药物为模型,研究自微乳释药系统的制备及体外评价方法。方法制备岩黄连生物碱自微乳,以自微乳时间、所成微乳的形态、粒径分布、Zeta电位、含量、稳定性以及体外模拟人体释放等指标为考察项目,进行体外评价。结果所制备的自微乳载药量2.29 g.L-1,3 min内已基本乳化完全,乳化后粒子粒径大多数在20 nm左右,呈高斯分布,包封率大于98.7%,自微乳效率高。结论优选出的自乳化处方所制备的产品外观澄清透明,稳定性好,质量稳定,检测方法可靠,重现性好,展现了自微乳药物传统系统良好的释放特性。 OBJECTIVE To study the preparation and in vitro evaluation of self-microemulsifying (SME) drug delivery system with alkaloids from Corydalis saxicola Bunting(CSBA) . METHODS The Zeta potential, size distribution, dissolution and release in vitro of SME-CSBA were assessed. RESULTS SEM-CSBA was completely emulsifieated within 3 rain. Morphological studies revealed that uanosphcres were spilerieal in shape about 20 nm and gaussian distribution. High drug encapsulation efficiency was oblained. CONCLUSION SME-CSBA prepared with optimization prescription is limpid, good stability , easy to prepare with consistent quality, whose reliable determination method may be easily reproduced. The SMEDDS showed good release profiles as drug delivery systems.
出处 《中国药学杂志》 CAS CSCD 北大核心 2008年第21期1633-1637,共5页 Chinese Pharmaceutical Journal
关键词 岩黄连生物碱 自微乳 制备 体外评价 alkaloids from Corydalis saxieola Bunting self-mieroemulsiying drug delivery, system preparation in vitro evaluation
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