联合用药在心肺复苏中的应用研究

Study on the application of drug combination to cardiopulmonary resuscitation patients

目的探讨心肺复苏(CPR)中联用血管升压素、肾上腺素、氨茶碱及盐酸纳洛酮的临床效果。方法将心搏骤停患者58例行CPR,随机分为两组。联用肾上腺素标准剂量组(对照组)27例;联用血管升压素、肾上腺素、氨茶碱及盐酸纳洛酮组(研究组)31例。各组分别观察自主循环和呼吸恢复率、24h存活率及出院存活率、自主循环呼吸恢复时间。结果与对照组比较,研究组自主循环、呼吸恢复率、24h存活率及出院存活率明显高于对照组,差异有统计学意义(P<0.05);研究组自主循环呼吸恢复时间明显短于对照组,差异有统计学意义(P<0.05)。结论CPR联用血管升压素、肾上腺素、氨茶碱及盐酸纳洛酮能显著提高自主循环呼吸恢复率、24h存活率及出院存活率;缩短自主循环及呼吸恢复时间,是提高CPR成功率的较好方法。

Objective To explore clinical effects of drug combination including vasopressin, epinephrine, aminophylline and naloxone on cardiopulmonary resuscitation. Methods 58 patients with cardiac arrest were divided into research group and control group at random. 27 patients in control group were solely given epinephrine, and 31 patients in research group were given vasopressin combined with epinephrine, aminophylline and naloxone. The rate of spontaneous circulation and respiration restoration, the survival rate within 24 hours and the out - of - hospital survival rate, the average time of spontaneous circulation and respiration restoration were monitored in each group. Results The rates of spontaneous circulation and respiration restoration, the survival rate within 24 hours and the out - of - hospital survival rate in the research group were significantly higher than those in the control group （ P 〈 0.05 ）, the average time of spontaneous circulation and respiration restoration in the research group was significantly shorter than that in the control group（ P 〈 0.05 ）. Conclusions The drug combination of vasopressin, epinephrine, aminophylline and naloxone for cardiopulmonary resuscitation patients can obviously increase the rate of spontaneous circulation and respiration restoration, and the survival rate within 24 hours and the out - of - hospital survival rate. Average time of spontaneous circulation and respiration restoration was significantly shorter. The drug combination for cardiopulmonary resuscitation is new method to increase the successful rate of CPR.